Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency.
Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency.
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DOI：
10.1371/journal.pone.0033533
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wessling-Resnick M
中科院分区：
文献类型：
--
作者：
Kim J;Li Y;Buckett PD;Böhlke M;Thompson KJ;Takahashi M;Maher TJ;Wessling-Resnick M
缺铁大鼠铁反应性锰摄取增加，表明与锰暴露相关的毒性可通过铁状态进行修改。为了探索可能的相互作用，鼻内滴注锰在对照组和缺铁大鼠大脑中的分布特征在于使用T1加权磁共振成像（MRI）的定量图像分析。鼻内注射氯化锰1周或3周后，缺铁大鼠脑中锰的积累增加了一倍。在缺铁大鼠的特定脑区，包括纹状体、海马和前额皮质，观察到锰水平增加。缺铁大鼠花了减少的时间在一个标准的加速旋转棒下降前，并与较低的峰值速度相比，控制;出乎意料的是，这些措施的运动功能显着改善，在缺铁大鼠鼻内滴注氯化锰。虽然纹状体中组织多巴胺浓度相似，但锰灌注大鼠的多巴胺转运蛋白（DAT）和多巴胺受体D1（D1 R）水平降低，多巴胺受体D2（D2 R）水平升高，表明锰诱导的突触后多巴胺能信号传导的变化有助于代偿效应。缺铁时嗅觉锰吸收增强似乎是一种程序化的“救援反应”，对低铁状态引起的运动障碍具有有益影响。
Iron-responsive manganese uptake is increased in iron-deficient rats, suggesting that toxicity related to manganese exposure could be modified by iron status. To explore possible interactions, the distribution of intranasally-instilled manganese in control and iron-deficient rat brain was characterized by quantitative image analysis using T1-weighted magnetic resonance imaging (MRI). Manganese accumulation in the brain of iron-deficient rats was doubled after intranasal administration of MnCl2 for 1- or 3-week. Enhanced manganese level was observed in specific brain regions of iron-deficient rats, including the striatum, hippocampus, and prefrontal cortex. Iron-deficient rats spent reduced time on a standard accelerating rotarod bar before falling and with lower peak speed compared to controls; unexpectedly, these measures of motor function significantly improved in iron-deficient rats intranasally-instilled with MnCl2. Although tissue dopamine concentrations were similar in the striatum, dopamine transporter (DAT) and dopamine receptor D1 (D1R) levels were reduced and dopamine receptor D2 (D2R) levels were increased in manganese-instilled rats, suggesting that manganese-induced changes in post-synaptic dopaminergic signaling contribute to the compensatory effect. Enhanced olfactory manganese uptake during iron deficiency appears to be a programmed “rescue response” with beneficial influence on motor impairment due to low iron status.
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DOI：
10.1152/ajplung.00382.2004
发表时间：
2005-05-01
影响因子：
4.9
作者：
Heilig, E;Molina, R;Wessling-Resnick, M
通讯作者：
Wessling-Resnick, M
DOI：
10.1016/0378-4347(93)80311-q
发表时间：
1993-05-05
期刊：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS
影响因子：
--
作者：
GAMACHE, P;RYAN, E;ACWORTH, IN
通讯作者：
ACWORTH, IN
影响因子：
4.2
作者：
Lozoff, Betsy
通讯作者：
Lozoff, Betsy
影响因子：
4.2
作者：
Erikson, KM;Jones, BC;Beard, JL
通讯作者：
Beard, JL
影响因子：
3.8
作者：
Brenneman, KA;Wong, BA;Dorman, DC
通讯作者：
Dorman, DC