Modulation of cerebellar cortical, cerebellar nuclear and vestibular nuclear activity using alternating electric currents.
Modulation of cerebellar cortical, cerebellar nuclear and vestibular nuclear activity using alternating electric currents.
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DOI：
10.3389/fnsys.2023.1173738
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发表时间：
2023
影响因子：
3
通讯作者：
Lang, Eric J.
中科院分区：
文献类型：
--
作者：
Avlar, Billur;Rahman, Ramia;Vendidandi, Sai;Cetinkaya, Esma;Asan, Ahmet S.;Sahin, Mesut;Lang, Eric J.
关键词：
小脑经颅交流电刺激（ctACS）已显示出作为治疗各种神经系统疾病和影响正常学习过程的治疗方式的前景。然而，很少有人知道如何施加电流诱导的电场影响小脑活动在哺乳动物小脑在体内条件下。在麻醉大鼠的小脑表面施加频率为0.5至20 Hz的交流电（AC）刺激。从浦肯野细胞（PC），小脑和前庭核神经元，和其他小脑皮质神经元的细胞外记录。AC刺激调制所有类别的神经元的活动。小脑和前庭核神经元最经常表现出增加的尖峰活动在负相的AC刺激。浦肯野细胞简单的尖峰活动也增加了在负相在大多数位置，除了皮质直接低于刺激电极，其中活动最经常增加在AC周期的正相。其他皮质神经元表现出更混合，一般较弱的调制模式。浦肯野细胞反应的模式表明，AC刺激诱导一个复杂的电场，局部区域之间的幅度和方向的变化，可能反映了小脑皮质的折叠。感应电场的直接测量表明，它偏离了各向同性，均匀介质的径向场的理论预测显着，在其方向和幅度。这些结果与AC刺激在小脑中诱导的电场的模型相关。
Cerebellar transcranial alternating current stimulation (ctACS) has shown promise as a therapeutic modality for treating a variety of neurological disorders, and for affecting normal learning processes. Yet, little is known about how electric fields induced by applied currents affect cerebellar activity in the mammalian cerebellum under in vivo conditions. Alternating current (AC) stimulation with frequencies from 0.5 to 20 Hz was applied to the surface of the cerebellum in anesthetized rats. Extracellular recordings were obtained from Purkinje cells (PC), cerebellar and vestibular nuclear neurons, and other cerebellar cortical neurons. AC stimulation modulated the activity of all classes of neurons. Cerebellar and vestibular nuclear neurons most often showed increased spike activity during the negative phase of the AC stimulation. Purkinje cell simple spike activity was also increased during the negative phase at most locations, except for the cortex directly below the stimulus electrode, where activity was most often increased during the positive phase of the AC cycle. Other cortical neurons showed a more mixed, generally weaker pattern of modulation. The patterns of Purkinje cell responses suggest that AC stimulation induces a complex electrical field with changes in amplitude and orientation between local regions that may reflect the folding of the cerebellar cortex. Direct measurements of the induced electric field show that it deviates significantly from the theoretically predicted radial field for an isotropic, homogeneous medium, in both its orientation and magnitude. These results have relevance for models of the electric field induced in the cerebellum by AC stimulation.
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影响因子：
5.3
作者：
YEDLIN, M;KWAN, H;WONG, YC
通讯作者：
WONG, YC
影响因子：
5.5
作者：
CHAN, CY;HOUNSGAARD, J;NICHOLSON, C
通讯作者：
NICHOLSON, C
影响因子：
5.5
作者：
CHAN, CY;NICHOLSON, C
通讯作者：
NICHOLSON, C
影响因子：
2.6
作者：
Ferrucci R;Giannicola G;Rosa M;Fumagalli M;Boggio PS;Hallett M;Zago S;Priori A
通讯作者：
Priori A
DOI：
10.1523/jneurosci.3323-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blenkinsop TA;Lang EJ
通讯作者：
Lang EJ