Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience.
Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience.
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DOI：
10.1002/jso.23849
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发表时间：
2015-03-15
影响因子：
2.5
通讯作者：
Melstrom, Laleh G.
中科院分区：
文献类型：
--
作者：
Eng, Oliver S.;Tsang, Ashley T.;Moore, Dirk;Chen, Chunxia;Narayanan, Sumana;Gannon, Christopher J.;August, David A.;Carpizo, Darren R.;Melstrom, Laleh G.
结直肠癌肝转移的外科治疗不断发展，以优化肿瘤结局，同时最大限度地保护实质。术中微波消融术后的长期数据有限。本研究调查了接受术中微波消融的患者的复发结局和模式。对2009年至2013年在我院接受术中微波消融治疗结直肠癌肝转移的33例患者进行了回顾性分析。对围手术期和长期数据进行了审查，以确定复发的结局和模式。共治疗了49个肿瘤，大小范围为0.5-5.5 cm。Clavien-Dindo分级中位数为1级。中位随访时间为531天，13例（39.4%）患者出现复发。首次复发的中位时间为364天。在这些患者中，1例（7.8%）出现肝脏孤立性局部复发。7例大于3cm的肿瘤消融后仅1例复发（14.3%）。4年总生存率为35.2%，3.5年无病生存率为19.3%。没有围手术期变量预测全身或局部复发。术中微波消融是一种安全有效的方法，可用于治疗5.5 cm大的结直肠癌肝转移瘤。
Surgical management of colorectal cancer liver metastases continues to evolve to optimize oncologic outcomes while maximizing parenchymal preservation. Long-term data after intraoperative microwave ablation are limited. This study investigates outcomes and patterns of recurrence in patients who underwent intraoperative microwave ablation. A retrospective analysis of 33 patients who underwent intraoperative microwave ablation of colorectal cancer liver metastases from 2009 to 2013 at our institution was performed. Perioperative and long-term data were reviewed to determine outcomes and patterns of recurrence. A total of 49 tumors were treated, ranging 0.5–5.5 cm in size. Median Clavien–Dindo classification was one. Median follow-up was 531 days, with 13 (39.4%) patients presenting with a recurrence. Median time to first recurrence was 364 days. In those patients, 1 (7.8%) presented with an isolated local recurrence in the liver. Only 1 of 7 ablated tumors greater than 3 cm recurred (14.3%). Overall survival was 35.2% at 4 years, with a 19.3% disease-free survival at 3.5 years. No perioperative variables predicted systemic or local recurrence. Intraoperative microwave ablation is a safe and effective modality for use in the treatment of colorectal cancer liver metastases in tumors as large as 5.5 cm in size.
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影响因子：
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