Effect of age on the morphologies of the human Schlemm's canal and trabecular meshwork measured with swept‑source optical coherence tomography.
Effect of age on the morphologies of the human Schlemm's canal and trabecular meshwork measured with swept‑source optical coherence tomography.
复制标题
使用扫频源光学相干断层扫描测量年龄对人类施莱姆氏管和小梁网形态的影响
DOI：
10.1038/s41433-018-0148-6
复制
发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Chen Z;Sun J;Li M;Liu S;Chen L;Jing S;Cai Z;Xiang Y;Song Y;Zhang H;Wang J
我们的目的是测量健康人的Schlemm管(SC)和小梁网(TM)的大小，并利用扫描源光学相干断层扫描(OCT)评估从儿童到老年随年龄的变化。用扫描源OCT对右眼和左眼的上、下、鼻和颞区进行前房角成像。从OCT图像手动测量SC和TM的直径和面积、宽度和厚度。共有114名健康人入选，其中男性48名，女性66名，年龄从7岁到83岁不等。随着年龄的增长，四个象限的SC直径和面积均显着减小(P <； 0.001)，且鼻侧和颞侧上、下象限的SC直径和面积均较上、下象限宽。SC的大小变化与眼轴长度(AL)和前房深度呈显著正相关(P <； 0.001)。在鼻侧和颞侧象限中，年龄与TM厚度呈显著正相关(P <； 0.05)。下象限TM宽度是象限最宽的。上象限TM厚度在象限中最薄。鼻、颞象限TM厚度的变化与AL呈显著负相关(P< <； <0.05)。SC和TM参数与中央角膜厚度、眼压、性别、右眼或左眼无统计学意义的相关性(P >； 0.05)。随着年龄的增长，肌层直径和面积变小，肌层厚度增加，肌层宽度基本不变。扫描源OCT测量青光眼的SC和TM的大小有助于青光眼的临床评估和治疗计划。
We aimed to measure the sizes of Schlemm’s canal (SC) and the trabecular meshwork (TM) in healthy individuals and to evaluate variations with age from childhood to old age by using swept-source optical coherence tomography (OCT). Anterior chamber angle imaging of the superior, inferior, nasal, and temporal regions of the right and left eyes was performed with swept-source OCT. The diameter and area of SC and TM width and thickness were measured manually from OCT images. A total of 114 healthy individuals were enrolled and included 48 male subjects and 66 female subjects; their ages ranged from 7 to 83 years. Both the SC diameter and area in the four quadrants decreased significantly with aging (P < 0.001) and were wider in the nasal and temporal quadrants compared with the superior and inferior quadrants. Changes in SC size showed significant positive correlations with axial length (AL) and anterior chamber depth (P < 0.001). There was a significant positive association between age and TM thickness in the nasal and temporal quadrants (P < 0.05). The inferior quadrant TM width was the widest among the quadrants. The superior quadrant TM thickness was the thinnest among the quadrants. Changes in TM thickness in the nasal and temporal quadrants showed a significant negative correlation with AL (P < 0.05). There was no statistically significant correlation in SC and TM parameters with central corneal thickness, intraocular pressure, sex, or right or left eye (P > 0.05). With aging, the SC diameter and area became smaller, TM thickness increased, and TM width seemed to remain constant. Measurements of the sizes of SC and the TM with swept-source OCT could assist in clinical assessments and treatment planning for glaucoma.
登录
查看更多内容
影响因子：
17.8
作者：
Salmon, JF
通讯作者：
Salmon, JF
影响因子：
--
作者：
JOCSON, VL;SEARS, ML
通讯作者：
SEARS, ML
影响因子：
3.4
作者：
GRIERSON, I;HOWES, RC;WANG, Q
通讯作者：
WANG, Q
影响因子：
--
作者：
SOMMER, A;TIELSCH, JM;SINGH, K
通讯作者：
SINGH, K
影响因子：
4.2
作者：
BECKER, B
通讯作者：
BECKER, B