Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study.
Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study.
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DOI：
10.1002/art.24172
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发表时间：
2009-02-15
影响因子：
--
通讯作者：
Kremers, Hilal Maradit
中科院分区：
文献类型：
--
作者：
Wilson, Floranne C.;Icen, Murat;Crowson, Cynthia S.;Mcevoy, Marian T.;Gabriel, Sherine E.;Kremers, Hilal Maradit
确定银屑病患者中临床公认的银屑病关节炎 (PsA) 的发病率和疾病特异性预测因子。我们确定了 1970 年 1 月 1 日至 1999 年 12 月 31 日期间在以人群为基础的环境中诊断的年龄≥18 岁的银屑病受试者的发病队列。银屑病诊断通过病历中的确诊进行验证。事件和临床认可的 PsA 受试者根据银屑病关节炎分类 (CASPAR) 标准进行分类。 Cox 比例风险模型用于确定银屑病队列中 PsA 的预测因素。银屑病发病队列由 1,633 名受试者组成。其中，40 人被诊断出同时患有银屑病关节炎和银屑病，并被排除在分析之外。其余 1,593 名银屑病受试者的平均年龄为 43 岁，其中 50% 为男性。在超过 20,936 人年的随访中，57 名受试者被临床识别为新发 PsA，在 5、10、10 日的累积发生率为 1.7%（95% 置信区间 [95% CI] 1.0–2.3%）、3.1%（95% CI 2.2–4.1%）和 5.1%（95% CI 3.7–6.6%）。和银屑病发病后 20 年。与银屑病关节炎高风险相关的银屑病特征包括头皮病变（风险比 [HR] 3.89，95% CI 2.18–6.94）、指甲营养不良（HR 2.93，95% CI 1.68–5.12）和臀间/肛周病变（HR 2.35，95% CI 1.32–4.19）。日历年份与 PsA 风险无关（P = 0.15），表明银屑病受试者患 PsA 的可能性不会随时间变化。在这项基于人群的研究中，不到 10% 的银屑病患者在 30 年内发展为临床公认的银屑病关节炎。与银屑病关节炎较高可能性相关的银屑病特征是指甲营养不良、头皮病变和臀间/肛周银屑病。
To determine the incidence and disease-specific predictors of clinically recognized psoriatic arthritis (PsA) in patients with psoriasis. We identified an incidence cohort of psoriasis subjects age ≥18 years diagnosed between January 1, 1970 and December 31, 1999 in a population-based setting. Psoriasis diagnoses were validated by confirmatory diagnosis in the medical record. Incident and clinically recognized PsA subjects were classified according to the Classification of Psoriatic Arthritis (CASPAR) criteria. Cox proportional hazards models were used to identify predictors of PsA within the psoriasis cohort. The psoriasis incidence cohort comprised 1,633 subjects. Of these, 40 were diagnosed with PsA concurrently with psoriasis and were excluded from analysis. The remaining 1,593 psoriasis subjects had a mean age of 43 years and 50% were men. Over 20,936 person-years of followup, 57 subjects were clinically recognized with new-onset PsA, with a cumulative incidence of 1.7% (95% confidence interval [95% CI] 1.0–2.3%), 3.1% (95% CI 2.2– 4.1%), and 5.1% (95% CI 3.7–6.6%) at 5, 10, and 20 years following psoriasis incidence, respectively. Psoriasis features associated with higher risk of PsA were scalp lesions (hazard ratio [HR] 3.89, 95% CI 2.18–6.94), nail dystrophy (HR 2.93, 95% CI 1.68–5.12), and intergluteal/perianal lesions (HR 2.35, 95% CI 1.32–4.19). Calendar year was not associated with risk of PsA (P = 0.15), indicating that the likelihood of PsA in psoriasis subjects did not change over time. In this population-based study, <10% of patients with psoriasis developed clinically recognized PsA during a 30-year period. Psoriasis features associated with a higher likelihood of PsA were nail dystrophy, scalp lesions, and intergluteal/perianal psoriasis.
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DOI：
10.1016/s0950-3579(94)80024-3
发表时间：
1994-05-01
期刊：
BAILLIERES CLINICAL RHEUMATOLOGY
影响因子：
--
作者：
GLADMAN, DD
通讯作者：
GLADMAN, DD
DOI：
10.1016/s0950-3579(94)80017-0
发表时间：
1994-05-01
期刊：
BAILLIERES CLINICAL RHEUMATOLOGY
影响因子：
--
作者：
ONEILL, T;SILMAN, AJ
通讯作者：
SILMAN, AJ
影响因子：
4.4
作者：
Ackermann, Christoph;Kavanaugh, Arthur
通讯作者：
Kavanaugh, Arthur
影响因子：
27.4
作者：
Gladman, DD;Antoni, C;Nash, P
通讯作者：
Nash, P
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P