Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis.
Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis.
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DOI：
10.1016/j.ejrad.2020.109393
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发表时间：
2020-12
影响因子：
3.3
通讯作者：
Lee MK
中科院分区：
文献类型：
--
作者：
Choi Y;Lee MK
急性/亚急性梗死的患病率在有神经系统症状的COVID-19患者中最常见。脑微出血（6.9%）和自发性ICH（5.4%）的患病率相似。脑炎/脑病的患病率（3.3%）较低。通过系统综述和荟萃分析，全面评价COVID-19患者神经影像学异常结果的发生率。检索PubMed-MEDLINE和EMBASE，以查找2020年1月1日至2020年10月9日期间报告成年COVID-19患者脑部成像结果的原始文章。异常的神经影像学表现分为（1）脑微血管病变，（2）急性自发性颅内出血（ICH），（3）急性至亚急性梗死，和（4）脑炎或脑病。使用随机效应模型评估神经影像学结果的合并发生率。使用汇总发生率的χ2统计量和不一致性指数I2探索研究间异质性。使用非随机研究偏倚风险评估工具评价研究质量。进行亚组荟萃回归分析，以确定异质性的潜在来源。确定了21篇合格论文，包括2125例患者。脑微血管病、急性自发性ICH、急性/亚急性梗死和脑炎/脑病的合并发生率为6.9%（95%置信区间[CI]，4.9%-8.9%）、5.4%（95% CI，3.1%-7.6%）、24.0%（95% CI，16.1%-31.8%）和3.3%（95% CI，1.9%-4.7%）。注意到所有神经影像学结果均存在显著异质性（I2 = 87%-97%）。汇总发生率中存在显著的出版偏倚。在亚组荟萃回归分析中，平均或中位年龄超过65岁的患者显示脑炎/脑病的发病率显著降低（P < 0.001）。此外，研究报告ICU患者的脑微血管病（P < 0.001）和脑炎/脑病（P < 0.001）的发生率显著较高。在COVID-19患者中，已报告了相当多的异常神经影像学结果。急性至亚急性脑梗死是最常见的神经影像学表现。
The prevalence of acute/subacute infarcts was the most common in COVID-19 patients with neurologic symptoms. Cerebral microhemorrhages (6.9 %) and spontaneous ICH (5.4 %) were similarly prevalent. The prevalence of encephalitis/encephalopathy (3.3 %) was less frequent. To comprehensively evaluate the incidences of abnormal neuroimaging findings in patients with COVID-19 via a systematic review and meta-analysis. PubMed-MEDLINE and EMBASE were searched for original articles reporting imaging findings of the brain in adult patients with COVID-19 between January 1, 2020 and October 9, 2020. Abnormal neuroimaging findings were categorized as (1) cerebral microhemorrhages, (2) acute spontaneous intracranial hemorrhage (ICH), (3) acute to subacute infarcts, and (4) encephalitis or encephalopathy. Pooled incidences of neuroimaging findings were assessed using random-effects modeling. Between-study heterogeneity was explored by using the χ2 statistic for pooled incidences and the inconsistency index I2. The quality of the studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies. Subgroup meta-regression analysis was performed to identify potential sources of heterogeneity. Twenty-one eligible papers, including 2125 patients, were identified. The pooled incidences of cerebral microhemorrhages, acute spontaneous ICH, acute/subacute infarcts, and encephalitis/encephalopathy were 6.9 % (95 % confidence interval [CI], 4.9 %–8.9 %), 5.4 % (95 % CI, 3.1 %–7.6 %), 24.0 % (95 % CI, 16.1 %–31.8 %), and 3.3 % (95 % CI, 1.9 %–4.7 %), respectively. Substantial heterogeneities were noted for all neuroimaging findings (I2 = 87 %–97 %). Significant publication biases were present in the pooled incidences. In the subgroup meta-regression analysis, patients with mean or median ages over 65 years showed a significantly lower incidence of encephalitis/encephalopathy (P < 0.001). Furthermore, studies reported that patients in ICU had significantly higher incidences of cerebral microhemorrhages (P < 0.001) and encephalitis/encephalopathy (P < 0.001). Considerable incidences of abnormal neuroimaging findings have been reported in patients with COVID-19. Acute to subacute cerebral infarction was the most prevalent neuroimaging finding.
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影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
2.4
作者：
Fitsiori, Aikaterini;Pugin, Deborah;Vargas, Maria Isabel
通讯作者：
Vargas, Maria Isabel
影响因子：
15.1
作者：
Lu, Yiping;Li, Xuanxuan;Yin, Bo
通讯作者：
Yin, Bo
影响因子：
4.4
作者：
Jain, Rajan;Young, Matthew;Horwtiz, Leora
通讯作者：
Horwtiz, Leora
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N