G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation.
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation.
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DOI：
10.1124/molpharm.121.000302
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发表时间：
2022-04
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link in targeting hyperactivated mTORC1 in human disease. In this mini-review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor signaling to mTORC1. mTORC1 is a master regulator of many cellular processes and is often hyperactivated in human disease. Therefore, understanding the molecular underpinnings of G-protein coupled receptor signaling to mTORC1 will undoubtedly be beneficial for human disease.
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影响因子：
4.6
作者：
Di Mise A;Tamma G;Ranieri M;Centrone M;van den Heuvel L;Mekahli D;Levtchenko EN;Valenti G
通讯作者：
Valenti G
影响因子：
--
作者：
de Wit RH;Mujić-Delić A;van Senten JR;Fraile-Ramos A;Siderius M;Smit MJ
通讯作者：
Smit MJ
影响因子：
50.3
作者：
Dolma S;Selvadurai HJ;Lan X;Lee L;Kushida M;Voisin V;Whetstone H;So M;Aviv T;Park N;Zhu X;Xu C;Head R;Rowland KJ;Bernstein M;Clarke ID;Bader G;Harrington L;Brumell JH;Tyers M;Dirks PB
通讯作者：
Dirks PB
影响因子：
64.5
作者：
Demetriades C;Doumpas N;Teleman AA
通讯作者：
Teleman AA
影响因子：
4.6
作者：
Carnegie, Graeme K.;Means, Christopher K.;Scott, John D.
通讯作者：
Scott, John D.