Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies.
Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies.
复制标题
利用氧化还原的破坏来治疗相关的人类疱疹病毒8（HHV-8）。
DOI：
10.3390/antiox12010084
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发表时间：
2022-12-30
期刊：
影响因子：
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中科院分区：
文献类型：
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作者：
Reprogrammed metabolism is regarded as a hallmark of cancer and offers a selective advantage to tumor cells during carcinogenesis. The redox equilibrium is necessary for growth, spread and the antioxidant pathways are boosted following Reactive Oxygen Species (ROS) production to prevent cell damage in tumor cells. Human herpesvirus 8 (HHV-8), the etiologic agent of Kaposi sarcoma KS and primary effusion lymphoma (PEL), is an oncogenic virus that disrupts cell survival-related molecular signaling pathways leading to immune host evasion, cells growths, angiogenesis and inflammatory tumor-environment. We recently reported that primaquine diphosphate causes cell death by apoptosis in HHV-8 infected PEL cell lines in vivo and exhibits therapeutic anti-tumor activity in mice models and advanced KS. Our findings also suggest that the primaquine-induced apoptosis in PEL cells is mostly influenced by ROS production and targeting the redox balance could be a new approach to treat HHV-8 related diseases. In this review, we summarized the knowledge about the influence of ROS in cancer development; more specifically, the proof of evidence from our work and from the literature that redox pathways are important for the development of HHV-8 pathologies.
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影响因子：
20.3
作者：
Davis, DA;Rinderknecht, AS;Yarchoan, R
通讯作者：
Yarchoan, R
影响因子：
5.2
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Gothland A;Leducq V;Grange P;Faye O;Beauvais Remigereau L;Sayon S;Désiré N;Jary A;Laplantine E;Maiga AI;Dupin N;Marcelin AG;Calvez V
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Calvez V
影响因子：
4.5
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Ganesan, Shobana;Chaurasiya, Narayan D.;Tekwani, Babu L.
通讯作者：
Tekwani, Babu L.
影响因子：
7.3
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Finkel, Toren
通讯作者：
Finkel, Toren
影响因子：
158.5
作者：
CLAVELL, LA;GELBER, RD;SALLAN, SE
通讯作者：
SALLAN, SE