"Predictors of in-hospital mortality in adult cancer patients with COVID-19 infection presenting to the emergency department: A retrospective study".
"Predictors of in-hospital mortality in adult cancer patients with COVID-19 infection presenting to the emergency department: A retrospective study".
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“在急诊科呈现CoVID-19感染的成年癌症患者中的院内死亡率的预测指标：一项回顾性研究”。
DOI：
10.1371/journal.pone.0278898
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
El Zahran, Tharwat
中科院分区：
文献类型：
--
作者：
El Majzoub, Imad;Kalot, Nour;Khalifeh, Malak;Estelly, Natalie;El Zahran, Tharwat
成年癌症患者在COVID-19感染后的发病率和死亡率风险较高。作为第一线，急诊医生识别那些死亡风险较高的人至关重要。我们研究的目的是确定在急诊科就诊的COVID-19阳性癌症患者的院内死亡率的预测因素。这是一项对2020年2月21日至2021年2月21日期间到美国贝鲁特大学医学中心艾德就诊并被发现感染COVID-19的成年癌症患者进行的回顾性队列研究。提取相关数据并进行分析。使用Student t检验和Fisher精确检验或Pearson卡方检验（如适用）检验不同变量与住院死亡率之间的相关性。Logistic回归应用于单变量模型中p <0.2的因素。该研究包括89名不同的患者，平均年龄为66岁（± 13.6）。超过一半的患者是吸烟者（52.8%），并在发病后1个月内接受过化疗（52.8%）。约三分之一的患者死亡（n = 31，34.8%）。近期接受过化疗的患者死亡率显著较高（67.7% vs 44.8%，p = 0.039），有充血性心力衰竭（CHF）病史（p = 0.04），CRP（p = 0.048）和/或PCT（p<0.04）水平较高，或在艾德时呼吸急促（P = 0.016）。如果患有COVID-19感染的成年癌症患者在就诊时出现呼吸急促、近期化疗、CHF病史、高CRP和高降钙素原水平，则其死亡风险较高。
Adult cancer patients are at higher risk of morbidity and mortality following COVID-19 infection. Being on the front lines, it is crucial for emergency physicians to identify those who are at higher risk of mortality. The aim of our study was to determine the predictors of in-hospital mortality in COVID-19 positive cancer patients who present to the emergency department. This is a retrospective cohort study conducted on adult cancer patients who presented to the ED of the American university of Beirut medical center from February 21, 2020, till February 21, 2021, and were found to have COVID-19 infection. Relevant data was extracted and analyzed. The association between different variables and in-hospital mortality was tested using Student’s t test and Fisher’s exact test or Pearson’s Chi-square where appropriate. Logistic regression was applied to factors with p <0.2 in the univariate models. The study included 89 distinct patients with an average age of 66 years (± 13.6). More than half of them were smokers (52.8%) and had received chemotherapy within 1 month of presentation (52.8%). About one third of the patients died (n = 31, 34.8%). Mortality was significantly higher in patients who had recently received chemotherapy (67.7% vs 44.8%, p = .039), a history of congestive heart failure (CHF)(p = .04), higher levels of CRP (p = 0.048) and/or PCT(p<0.04) or were tachypneic in the ED (P = 0.016). Adult cancer patients with COVID-19 infection are at higher risks of mortality if they presented with tachypnea, had a recent chemotherapy, history of CHF, high CRP, and high procalcitonin levels at presentation.
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影响因子：
4.2
作者：
Goncalves, Pedro Falcao;Falcao, Luiz Menezes;Pinheiro, Isabel Duque
通讯作者：
Pinheiro, Isabel Duque
影响因子：
4.4
作者：
Chatterjee NA;Jensen PN;Harris AW;Nguyen DD;Huang HD;Cheng RK;Savla JJ;Larsen TR;Gomez JMD;Du-Fay-de-Lavallaz JM;Lemaitre RN;McKnight B;Gharib SA;Sotoodehnia N
通讯作者：
Sotoodehnia N
DOI：
10.1073/pnas.2004064117
发表时间：
2020-04-21
影响因子：
11.1
作者：
Moghadas, Seyed M.;Shoukat, Affan;Galvani, Alison P.
通讯作者：
Galvani, Alison P.
影响因子：
11.8
作者：
Ji, Dong;Zhang, Dawei;Qin, Enqiang
通讯作者：
Qin, Enqiang
影响因子：
3.2
作者：
Quah, Li Juan Joy;Tan, Boon Kiat Kenneth;Venkataraman, Anantharaman
通讯作者：
Venkataraman, Anantharaman