Pain sensitivity is inversely related to regional grey matter density in the brain.
Pain sensitivity is inversely related to regional grey matter density in the brain.
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DOI：
10.1016/j.pain.2013.12.004
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发表时间：
2014-03
期刊：
影响因子：
7.4
通讯作者：
Coghill RC
中科院分区：
文献类型：
--
作者：
Emerson NM;Zeidan F;Lobanov OV;Hadsel MS;Martucci KT;Quevedo AS;Starr CJ;Nahman-Averbuch H;Weissman-Fogel I;Granovsky Y;Yarnitsky D;Coghill RC
疼痛是一种高度个人化的体验，个体之间差异很大。为了寻找疼痛敏感性的解剖学相关性，我们使用基于体素的形态测量 (VBM) 来研究 116 名健康志愿者（62 名女性，54 名男性）的整个大脑灰质密度与疼痛敏感性个体间差异之间的关系。使用了之前 10 项功能磁共振成像研究的结构磁共振成像和心理物理学数据。年龄、性别、不愉快评级、扫描仪序列和感官测试位置作为协变量添加到模型中。全脑灰质密度和 49°C 热痛强度等级的回归分析显示，后扣带皮层、楔前叶、顶内沟和顶下小叶双侧区域的疼痛敏感性和灰质密度之间存在显着的负相关关系。左侧初级体感皮层的单侧区域也表现出这种反比关系。没有区域表现出与疼痛敏感性呈正相关。这些结构变化发生在与默认模式网络、注意力方向和转移以及体感处理相关的区域。这些发现强调了与默认模式思维和注意力相关的过程在塑造疼痛敏感性个体差异方面的潜在重要性，并表明疼痛敏感性可以根据大脑结构进行预测。
Pain is a highly personal experience that varies substantially among individuals. In search of an anatomical correlate of pain sensitivity we used voxel-based morphometry (VBM) to investigate the relationship between grey matter density across the whole brain and inter-individual differences in pain sensitivity in 116 healthy volunteers (62 females, 54 males). Structural MRI and psychophysical data from 10 previous fMRI studies were used. Age, sex, unpleasantness ratings, scanner sequence, and sensory testing location were added to the model as covariates. Regression analysis of grey matter density across the whole brain and thermal pain intensity ratings at 49°C revealed a significant inverse relationship between pain sensitivity and grey matter density in bilateral regions of the posterior cingulate cortex, precuneus, intraparietal sulcus, and inferior parietal lobule. Unilateral regions of the left primary somatosensory cortex also exhibited this inverse relationship. No regions exhibited a positive relationship to pain sensitivity. These structural variations occurred in areas associated with the default mode network, attentional direction and shifting, as well as somatosensory processing. These findings underscore the potential importance of processes related to default mode thought and attention in shaping individual differences in pain sensitivity and indicate that pain sensitivity can potentially be predicted on the basis of brain structure.
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影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
Tracey, I
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR
影响因子：
3.2
作者：
Corbetta, M;Kincade, JM;Shulman, GL
通讯作者：
Shulman, GL
DOI：
10.1016/j.juro.2011.03.027
发表时间：
2011-07
期刊：
The Journal of urology
影响因子：
--
作者：
Farmer MA;Chanda ML;Parks EL;Baliki MN;Apkarian AV;Schaeffer AJ
通讯作者：
Schaeffer AJ