Combination therapy of modified electroconvulsive therapy and long-acting injectable aripiprazole for dopamine supersensitivity psychosis: a case report
Combination therapy of modified electroconvulsive therapy and long-acting injectable aripiprazole for dopamine supersensitivity psychosis: a case report
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改良电惊厥疗法与长效注射用阿立哌唑联合治疗多巴胺超敏性精神病一例报告
DOI：
10.1080/13554794.2022.2114838
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发表时间：
2022
期刊：
影响因子：
0.8
通讯作者：
Otsuka Toshihiro
中科院分区：
文献类型：
--
作者：
Matsuzaka Yusuke;Noguchi Manabu;Kanamura Shigeki;Maeda Kengo;Hisano Takahiro;Tanaka Daizo;Ando Yukihiro;Yamamoto Tomokazu;Morimoto Yoshiro;Ozawa Hiroki;Otsuka Toshihiro
在精神分裂症的治疗中，长期使用D2受体拮抗剂可诱发多巴胺超敏性精神病（DSP）。我们报告一位男性精神分裂症患者，怀疑DSP由于过度多药。他在医院住了好几年。大多数精神药物减少，随后停止使用无抽搐电休克治疗（mECT），症状未加重。然后选择阿立哌唑作为治疗的主要药物，随后将其改为长效注射制剂。他最终出院回家。mECT和阿立哌唑的联合治疗，特别是长效注射制剂，可能有助于改善和预防DSP。
In the treatment of schizophrenia, long-term pharmacotherapy with D2-receptor antagonists can induce dopamine supersensitivity psychosis (DSP). We report a male patient with schizophrenia with suspected DSP due to excessive polypharmacy. He was hospitalized for several years. Most psychotropic drugs were reduced and subsequently stopped without the exacerbation of symptoms by administering modified electroconvulsive therapy (mECT). Aripiprazole was then selected as the main drug for treatment, which was subsequently changed to the long-acting injection formulation. He was eventually discharged and returned home. Combination therapy with mECT and aripiprazole, especially the long-acting injectable formulation, may help improve and prevent DSP.
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