Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains.
Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains.
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DOI：
10.1155/2018/7413504
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发表时间：
2018
影响因子：
--
通讯作者：
Wąsik TJ
中科院分区：
文献类型：
--
作者：
Kępa M;Miklasińska-Majdanik M;Wojtyczka RD;Idzik D;Korzeniowski K;Smoleń-Dzirba J;Wąsik TJ
酚类化合物具有多种生物活性，是最有前途和最普遍的一类化合物。天然酚类化合物与抗生素之间的协同相互作用可能为治疗多药耐药细菌提供一种理想的替代方法。本研究的目的是评估咖啡酸（CA）单独和抗生素-植物化学联合对感染伤口分离的金黄色葡萄球菌参考菌株和临床菌株的抗菌潜力。咖啡酸对金黄色葡萄球菌的最低抑菌浓度（MIC）为256 ~ 1024 μg/mL。添加1/4 MIC CA的Mueller-Hinton琼脂（MHA）可增强红霉素、克林霉素和头孢西丁的抗菌作用，而万古霉素的抗菌作用较弱。观察到CA的抑菌作用似乎是菌株依赖而不是抗生素依赖。我们的数据支持CA单独对金黄色葡萄球菌临床菌株具有抗菌活性的观点，并且与抗生素联合使用具有增强抗菌效果的能力。CA与抗生素之间的协同作用表明其作为一种新型抗菌工具的潜力，可以改善多药耐药菌株引起的难治性感染的治疗。
Phenolic compounds constitute one of the most promising and ubiquitous groups with many biological activities. Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective of the presented study was to assess the antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus reference and clinical strains isolated from infected wounds. The caffeic acid tested in the presented study showed diverse effects on S. aureus strains with the minimum inhibitory concentration (MIC) varied from 256 μg/mL to 1024 μg/mL. The supplementation of Mueller-Hinton agar (MHA) with 1/4 MIC of CA resulted in augmented antibacterial effect of erythromycin, clindamycin, and cefoxitin and to the lesser extent of vancomycin. The observed antimicrobial action of CA seemed to be rather strain than antibiotic dependent. Our data support the notion that CA alone exerts antibacterial activity against S. aureus clinical strains and has capacity to potentiate antimicrobial effect in combination with antibiotics. The synergy between CA and antibiotics demonstrates its potential as a novel antibacterial tool which could improve the treatment of intractable infections caused by multidrug-resistant strains.
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