Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth.
Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth.
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DOI：
10.1016/j.ajog.2010.09.021
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发表时间：
2011-05
影响因子：
9.8
通讯作者：
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
中科院分区：
文献类型：
--
作者：
Esplin MS;Merrell K;Goldenberg R;Lai Y;Iams JD;Mercer B;Spong CY;Miodovnik M;Simhan HN;van Dorsten P;Dombrowski M;Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
目的：探讨临产前无症状妇女随后自然早产(SPTB)的血清标志物。将血清蛋白质组学应用于24周时采集的80名孕妇和28周时采集的另外80名孕妇的血清。一半的人怀孕不复杂，一半的人患有SPTB。间α-胰蛋白酶抑制物重链4蛋白产生的三种特定多肽在随后发生SPTB的妇女24周和28周时显著减少。最具区分性的多肽的敏感性为65.0%，特异性为82.5%，OR=8.8，CI：3.1~24.8。在28周时，3个新的生物标记物和6个先前研究的生物标记物的组合将敏感性提高到86.5%，特异性为80.6%。应用血清蛋白质组学方法已鉴定出三种新的SPTB血清标志物。使用这些新的标志物和其他标志物的组合，可以在SPTB之前几周识别出有SPTB风险的妇女。
To identify serum markers of subsequent spontaneous preterm birth (SPTB) in asymptomatic women prior to labor. Serum proteomics was applied to sera from 80 pregnant women sampled at 24 weeks and an additional 80 pregnant women sampled at 28 weeks. Half had uncomplicated pregnancies and half SPTB. Three specific peptides arising from inter-alpha-trypsin inhibitor heavy chain 4 protein were significantly reduced in women at 24 and 28 weeks having subsequent SPTB. The most discriminating peptide had a sensitivity of 65.0% and specificity of 82.5%, OR=8.8, CI: 3.1-24.8. A combination of the 3 new biomarkers and 6 previously studied biomarkers increased sensitivity to 86.5% with a specificity of 80.6% at 28 weeks. Three novel serum markers of SPTB have been identified using serum proteomics. Using a combination of these new markers with additional markers, women at risk of SPTB can be identified weeks prior to SPTB.
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DOI：
10.1111/j.1471-0528.2004.00340.x
发表时间：
2005-02-01
影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
168.9
作者：
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通讯作者：
Liotta, LA
影响因子：
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作者：
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通讯作者：
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