Vaccines for the 21st century.
Vaccines for the 21st century.
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DOI：
10.1002/emmm.201403876
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发表时间：
2014-06
影响因子：
11.1
通讯作者：
De Gregorio, Ennio
中科院分区：
文献类型：
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作者：
Delany, Isabel;Rappuoli, Rino;De Gregorio, Ennio
在上个世纪，疫苗接种一直是减少传染病造成的死亡和发病率的最有效的医疗干预措施。据信，全球每年至少有200-300万人因接种疫苗而获救。通过全球疫苗运动，天花已被根除，小儿麻痹症在全世界几乎消失。由于发达国家的国家免疫计划，传统上影响儿童的大多数病毒和细菌感染已大幅减少。然而，许多疾病尚不能通过接种疫苗来预防，针对老年人和孕妇等目标人群的疫苗尚未得到充分利用。这篇综述侧重于针对艾滋病毒、疟疾、结核病和癌症等未得到满足的主要医疗需求的疫苗的最新临床试验的最新进展。此外，我们描述了目前在疫苗研究和开发中使用的创新技术，包括佐剂、载体、核酸疫苗和基于结构的抗原设计。人们希望，由于这些技术，21世纪将有更多的疾病通过新型预防和治疗性疫苗得到解决。
In the last century, vaccination has been the most effective medical intervention to reduce death and morbidity caused by infectious diseases. It is believed that vaccines save at least 2–3 million lives per year worldwide. Smallpox has been eradicated and polio has almost disappeared worldwide through global vaccine campaigns. Most of the viral and bacterial infections that traditionally affected children have been drastically reduced thanks to national immunization programs in developed countries. However, many diseases are not yet preventable by vaccination, and vaccines have not been fully exploited for target populations such as elderly and pregnant women. This review focuses on the state of the art of recent clinical trials of vaccines for major unmet medical needs such as HIV, malaria, TB, and cancer. In addition, we describe the innovative technologies currently used in vaccine research and development including adjuvants, vectors, nucleic acid vaccines, and structure-based antigen design. The hope is that thanks to these technologies, more diseases will be addressed in the 21st century by novel preventative and therapeutic vaccines.
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影响因子：
3.7
作者：
Brooks A;Briët OJ;Hardy D;Steketee R;Smith TA
通讯作者：
Smith TA
影响因子：
17.1
作者：
Dormitzer, Philip R.;Suphaphiphat, Pirada;Venter, J. Craig
通讯作者：
Venter, J. Craig
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.
影响因子：
30.3
作者：
Burton DR;Ahmed R;Barouch DH;Butera ST;Crotty S;Godzik A;Kaufmann DE;McElrath MJ;Nussenzweig MC;Pulendran B;Scanlan CN;Schief WR;Silvestri G;Streeck H;Walker BD;Walker LM;Ward AB;Wilson IA;Wyatt R
通讯作者：
Wyatt R
影响因子：
64.8
作者：
通讯作者：
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