On the lineage of Aspergillus fumigatus isolates in common laboratory use.

On the lineage of Aspergillus fumigatus isolates in common laboratory use.
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DOI:
10.1093/mmy/myaa075
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发表时间:
2021-01-04
期刊:
影响因子:
2.9
通讯作者:
Bignell EM
Bignell EM
中科院分区:
医学3区
文献类型:
--
作者:
Bertuzzi M;van Rhijn N;Krappmann S;Bowyer P;Bromley MJ;Bignell EM

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烟曲霉研究人员社区经常使用的分离物的起源是我们中心定期进行激烈讨论的问题,因为重组分离物的构建有时遵循错综复杂的路线,描述其谱系的文件是零散的,并且命名令人困惑。作为一个辅助回忆录,尤其是为了我们自己的利益,我们提交了以下的帐户和列表的菌株(表1),以努力整理所有相关信息在一个单一的,易于访问的文件。为了最大限度地提高这一记录的准确性,我们广泛咨询了使用这些菌株的医学真菌学家社区。所有描述的菌株目前可从这些组织之一获得,即真菌遗传学库存中心(FGSC),FungiDB,Ensembl Fungi和英格兰公共卫生部的国家病原真菌保藏中心(NCPF)。该手稿中的展示物品也出现在FungiDB上。我们提出了一个简明扼要的概述真菌研究界经常使用的烟曲霉菌株的定义,起源和独特的遗传组成,以帮助研究人员更准确地描述过去和新的菌株和观察到的实验差异。
The origin of isolates routinely used by the community of Aspergillus fumigatus researchers is periodically a matter of intense discussion at our centre, as the construction of recombinant isolates have sometimes followed convoluted routes, the documentation describing their lineages is fragmented, and the nomenclature is confusing. As an aide memoir, not least for our own benefit, we submit the following account and tabulated list of strains (Table 1) in an effort to collate all of the relevant information in a single, easily accessible document. To maximise the accuracy of this record we have consulted widely amongst the community of Medical Mycologists using these strains. All the strains described are currently available from one of these organisations, namely the Fungal Genetics Stock Centre (FGSC), FungiDB, Ensembl Fungi and The National Collection of Pathogenic Fungi (NCPF) at Public Health England. Display items from this manuscript are also featured on FungiDB. We present a concise overview on the definition, origin and unique genetic makeup of the Aspergillus fumigatus isolates routinely in use by the fungal research community, to aid researchers to describe past and new strains and the experimental differences observed more accurately.
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