Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.
Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.
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海马振荡的光遗传学调节可以改善早期癫痫发作后的空间认知和海马运动障碍。
DOI：
10.1016/j.nbd.2023.106021
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发表时间：
2023-03
影响因子：
6.1
通讯作者：
Holmes GL
中科院分区：
文献类型：
--
作者：
Velasquez F;Dickson C;Kloc ML;Schneur CA;Barry JM;Holmes GL
越来越多的人类和动物证据表明，脑振荡在空间认知的发展中起着至关重要的作用。在幼鼠中，在记忆发育的关键时期通过光遗传学刺激破坏海马节律会损害空间认知。早期癫痫发作与空间认知的长期缺陷和海马振荡活动异常有关。在这里，我们询问是否调制海马节律后，早期生活癫痫发作可以逆转或改善海马连接和空间认知。我们使用光遗传学刺激的内侧隔诱导生理7赫兹θ振荡在海马在空间认知的关键时期后的早期生活癫痫发作。光遗传刺激的内侧隔在控制和大鼠进行早期生活癫痫发作导致精确调节频率匹配的海马振荡。在空间认知测试中，接受主动蓝光刺激的幼鼠比接受惰性黄光刺激的幼鼠表现更好。与接受惰性黄光的早期癫痫发作大鼠相比，这些大鼠空间认知的改善与海马中更快的θ频率和更高的θ功率、相干性和锁相值相关。这些发现表明，在生命早期癫痫发作后，海马节律的改变可能是一种潜在的新的治疗方式。
There is increasing human and animal evidence that brain oscillations play a critical role in the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition. Early-life seizures are associated with long-term deficits in spatial cognition and aberrant hippocampal oscillatory activity. Here we asked whether modulation of hippocampal rhythms following early-life seizures can reverse or improve hippocampal connectivity and spatial cognition. We used optogenetic stimulation of the medial septum to induce physiological 7 Hz theta oscillations in the hippocampus during the critical period of spatial cognition following early-life seizures. Optogenetic stimulation of the medial septum in control and rats subjected to early-life seizures resulted in precisely regulated frequency-matched hippocampal oscillations. Rat pups receiving active blue light stimulation performed better than the rats receiving inert yellow light in a test of spatial cognition. The improvement in spatial cognition in these rats was associated with a faster theta frequency and higher theta power, coherence and phase locking value in the hippocampus than rats with early-life seizures receiving inert yellow light. These findings indicate that following early life seizures, modification of hippocampal rhythms may be a potential novel therapeutic modality.
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作者：
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通讯作者：
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