T2 relaxation time post febrile status epilepticus predicts cognitive outcome.
T2 relaxation time post febrile status epilepticus predicts cognitive outcome.
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DOI：
10.1016/j.expneurol.2015.04.015
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发表时间：
2015-07
影响因子：
5.3
通讯作者：
Holmes, Gregory L.
中科院分区：
文献类型：
--
作者：
Barry, Jeremy M.;Choy, ManKin;Dube, Celine;Robbins, Ashlee;Obenaus, Andre;Lenck-Santini, Pierre Pascal;Scott, Rod C.;Baram, Tallie Z.;Holmes, Gregory L.
来自动物模型和患者数据的证据表明，早期发育的发热性癫痫状态(FSE)可导致永久性认知能力下降。为了了解FSE后认知结果的变异性，我们使用MRI来测量幼年大鼠对FSE诱导的动态脑代谢反应。然后，我们将这些测量结果与几周后学习主动回避空间任务的能力进行了比较。任务学习者的FSE大鼠的T2松弛时间显著低于非学习FSE的大鼠。虽然全脑的T2时间具有最大的预测力，但海马区和基底外侧杏仁核的T2时间也是很好的预测者。对FSE反应的这些信号差异表明，未能满足代谢和氧气需求的大鼠更有可能出现空间认知缺陷。与FSE学习者和对照动物相比，FSE非学习者的Place细胞具有更大的放电区域和更高的场内放电频率，这意味着FSE非学习者锥体细胞的兴奋性增加。这些发现提示了主动回避中空间记忆缺陷的机制原因，并与认知结果令人担忧的早期发育中的其他急性神经侮辱有关。
Evidence from animal models and patient data indicate that febrile status epilepticus (FSE) in early development can result in permanently diminished cognitive abilities. To understand the variability in cognitive outcome following FSE, we used MRI to measure dynamic brain metabolic responses to the induction of FSE in juvenile rats. We then compared these measurements to the ability to learn an active avoidance spatial task weeks later. T2 relaxation times were significantly lower in FSE rats that were task learners in comparison to FSE non-learners. While T2 time in whole brain held the greatest predictive power, T2 in hippocampus and basolateral amygdala were also excellent predictors. These signal differences in response to FSE indicate that rats that fail to meet metabolic and oxygen demand are more likely to develop spatial cognition deficits. Place cells from FSE non-learners had significantly larger firing fields and higher in-field firing rate than FSE learners and control animals and implies increased excitability in the pyramidal cells of FSE non-learners. These findings suggest a mechanistic cause for the spatial memory deficits in active avoidance and are relevant to other acute neurological insults in early development where cognitive outcome is a concern.
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影响因子：
11.2
作者：
Hesdorffer, Dale C.;Benn, Emma K. T.;Bagiella, Emilia;Nordli, Douglas;Pellock, John;Hinton, Veronica;Shinnar, Shlomo
通讯作者：
Shinnar, Shlomo
影响因子：
5.3
作者：
Lenck-Santini, Pierre-Pascal;Holmes, Gregory L.
通讯作者：
Holmes, Gregory L.
影响因子：
6.1
作者：
Jansen, Jacobus F. A.;Lemmens, Evi M. P.;Hoogland, Govert
通讯作者：
Hoogland, Govert
影响因子：
82.9
作者：
Chen, K;Baram, TZ;Soltesz, I
通讯作者：
Soltesz, I
影响因子：
5.6
作者：
Huang, CC;Wang, ST;Tsai, JJ
通讯作者：
Tsai, JJ