Lipidomic insight into cardiovascular diseases.

Lipidomic insight into cardiovascular diseases.
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对心血管疾病的脂质组学见解。

DOI:
10.1016/j.bbrc.2018.04.106
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发表时间:
2018-10-07
影响因子:
3.1
通讯作者:
Miyazaki M
Miyazaki M
中科院分区:
生物学4区
文献类型:
--
作者:
Kohno S;Keenan AL;Ntambi JM;Miyazaki M

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心血管疾病是全世界死亡的主要原因。因此,识别预测心血管事件的敏​​感分子标记并指出可延长寿命的治疗策略具有重要意义。脂质代谢失调被认为是心血管疾病的既定危险因素。然而,目前仍不清楚哪些特定的脂质分子种类可以反映心血管风险。此外,了解血管病理生理学中的整个脂质组特征具有挑战性。质谱技术的最新进展使研究人员能够从无偏差的小样本中检测每种脂质。在这篇综述中,我们更新了心血管疾病脂质组学方法的当前研究。
Cardiovascular disease is a primary cause of mortality worldwide. Therefore, it is of major interest to identify sensitive molecular markers that predict cardiovascular events and point to therapeutic strategies that will increase lifespans. Dysregulated lipid metabolism is recognized as an established risk factor in cardiovascular diseases. However, it is still largely unknown which specific lipid molecular species reflect cardiovascular risk. In addition, understanding the whole lipidome signature in vascular pathophysiology is challenging. Recent advancements of mass-spectrometry allow researchers to detect each individual lipid species from unbiased small samples. In this review, we update the current research on lipidomic approaches in cardiovascular diseases.
大规模代谢组分析确定了出现冠心病的新生物标志物。
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