Tat is a multifunctional viral protein that modulates cellular gene expression and functions.
Tat is a multifunctional viral protein that modulates cellular gene expression and functions.
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DOI：
10.18632/oncotarget.15174
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发表时间：
2017-04-18
期刊：
影响因子：
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通讯作者：
Caputi M
中科院分区：
文献类型：
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作者：
Clark E;Nava B;Caputi M
I 型人类免疫缺陷病毒 (HIV-1) 已开发出多种策略来调节宿主环境，以促进病毒复制和传播。病毒蛋白已经进化出多种功能，帮助病毒基因组复制并调节细胞对感染的反应。 Tat 是一种小型、多功能的病毒蛋白，它控制 HIV 基因组的转录，调节细胞基因表达，并通过改变免疫反应和促进病毒传播到多个组织来为病毒复制创造宽松的环境。利用生化、细胞和基因组方法进行的研究表明，Tat 通过多种机制调节数百个基因和多个分子网络的表达和活性。
The human immunodeficiency virus type I (HIV-1) has developed several strategies to condition the host environment to promote viral replication and spread. Viral proteins have evolved to perform multiple functions, aiding in the replication of the viral genome and modulating the cellular response to the infection. Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by altering the immune response and facilitating viral spread to multiple tissues. Studies carried out utilizing biochemical, cellular, and genomic approaches show that the expression and activity of hundreds of genes and multiple molecular networks are modulated by Tat via multiple mechanisms.
影响因子：
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作者：
Asensio VC;Campbell IL
通讯作者：
Campbell IL