Chemokines and viral diseases of the central nervous system.
Chemokines and viral diseases of the central nervous system.
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DOI：
10.1016/s0065-3527(01)56006-6
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发表时间：
2001
影响因子：
--
通讯作者：
Campbell IL
中科院分区：
文献类型：
--
作者：
Asensio VC;Campbell IL
本章讨论趋化因子及其受体在中枢神经系统(CNS)病毒感染性疾病进化中的作用。人中枢神经系统感染多种病毒或啮齿动物中枢神经系统感染可引起强烈的宿主炎症反应，大量白细胞聚集，尤其是T淋巴细胞和巨噬细胞。趋化因子通过刺激外周血白细胞的趋化、黏附、外渗和其他效应功能来协调外周血白细胞的运输。鉴于这些特性，越来越多的研究努力转向趋化因子在病毒感染期间调节外周组织和中枢神经系统白细胞迁移的可能参与。趋化因子的生物学效应是通过它们与七种跨膜G蛋白偶联受体(GPCRs)家族的受体相互作用而实现的。在正常的哺乳动物中枢神经系统中，大脑中存在的白细胞数量很少。然而，这些细胞被吸引到各种病理状态，并在其中积累，其中许多涉及病毒感染。虽然白细胞迁移到局部组织间，如中枢神经系统，是一个多因素的过程，但已清楚的是，趋化因子是这一过程的关键成分，为白细胞募集提供必要的趋化信号。
This chapter discusses chemokines and their receptors in the evolution of viral infectious diseases of the central nervous system (CNS). Infection of the human CNS with many different viruses or infection of the rodent CNS induces vigorous host-inflammatory responses with recruitment of large numbers of leukocytes, particularly T lymphocytes and macrophages. Chemokines coordinate trafficking of peripheral blood leukocytes by stimulating their chemotaxis, adhesion, extravasation, and other effector functions. In view of these properties, research efforts have turned increasingly to the possible involvement of chemokines in regulating both peripheral tissue and CNS leukocyte migration during viral infection. The biological effects of chemokines are mediated via their interaction with receptors belonging to the family of seven transmembrane (7TM)-spanning, G-protein coupled receptors (GPCRs). In the normal mammalian CNS, the number of leukocytes present in the brain is scant. However, these cells are attracted to, and accumulate in, a variety of pathologic states, many involving viral infection. Although leukocyte migration into local tissue compartments, such as the CNS, is a multifactorial process, it has become clear that chemokines are pivotal components of this process, providing a necessary chemotactic signal for leukocyte recruitment.
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影响因子：
3.7
作者：
Arai, M;Ohashi, T;Fujii, M
通讯作者：
Fujii, M
DOI：
10.1073/pnas.94.5.1925
发表时间：
1997-03-04
影响因子：
11.1
作者：
Bleul, CC;Wu, LJ;Mackay, CR
通讯作者：
Mackay, CR
影响因子：
3.3
作者：
Bell, MD;Taub, DD;Perry, VH
通讯作者：
Perry, VH
DOI：
10.1084/jem.188.5.855
发表时间：
1998-09-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bodaghi B;Jones TR;Zipeto D;Vita C;Sun L;Laurent L;Arenzana-Seisdedos F;Virelizier JL;Michelson S
通讯作者：
Michelson S
影响因子：
15.3
作者：
Bonecchi, R;Bianchi, G;Bordignon, P P;D'Ambrosio, D;Lang, R;Borsatti, A;Sozzani, S;Allavena, P;Gray, P A;Mantovani, A;Sinigaglia, F
通讯作者：
Sinigaglia, F