Concordance of nasal and diabetic foot ulcer staphylococcal colonization.

Concordance of nasal and diabetic foot ulcer staphylococcal colonization.
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DOI:
10.1016/j.diagmicrobio.2014.01.014
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发表时间:
2014-05
影响因子:
2.9
通讯作者:
Gardner, Sue E.
Gardner, Sue E.
中科院分区:
医学4区
文献类型:
--
作者:
Haleem, Ambar;Schultz, Jonathan S.;Heilmann, Kristopher P.;Dohrn, Cassie L.;Diekema, Daniel J.;Gardner, Sue E.

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Nasal carriage of Staphylococcus aureus (SA) is an important risk factor for surgical site infections. The goal of this study was to investigate the concordance between nasal and diabetic foot ulcer (DFU) SA carriage. 79 subjects with DFUs were assessed for nasal and DFU colonization with SA, including Methicillin-resistant-SA (MRSA). Twenty-five (31.6%) subjects had nares colonization with SA; 29 (36.7%) had DFU colonization with SA. Seven (8.8%) subjects had nares colonization with MRSA and 7 (8.8%) had DFU colonization with MRSA. Ulcer duration was associated with MRSA presence (p=0.01). Sensitivity and specificity of positive nasal SA colonization with positive DFU colonization were 41 and 74%. We found substantial discordance between SA strains colonizing DFU and the nasal cavity. The poor positive predictive values for SA isolation in a DFU based on nasal carriage suggests SA colonization of a DFU by endogenous SA strains cannot be assumed.
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