The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project.
The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project.
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DOI：
10.1017/thg.2023.8
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发表时间：
2023-02
影响因子：
0.9
通讯作者：
Prom-Wormley, Elizabeth C.
中科院分区：
文献类型：
--
作者：
Vanyukov, Michael M.;Maes, Hermine H. M.;Iacono, William G.;Kirisci, Levent;Samek, Diana R.;Silberg, Judy L.;Zimmerman, Emily B.;Prom-Wormley, Elizabeth C.
非法药物使用在急性和慢性形式都是危险的，经常导致致命中毒、成瘾和其他负面后果。类似于对其他精神疾病的研究，其最终目标是实现有效的预防和治疗，对物质使用的研究侧重于提高疾病风险的因素。然而，尽管投入了努力与之斗争，但药物使用问题的迅速增长表明，有必要改变研究方法。与其试图确定风险因素，这些因素的消除往往是不可实现的，如果不是不可能的话，不如系统地将观点扭转到增强与风险具有相同维度但相反的障碍责任方面的因素，即对药物使用的抵制，可能更有希望。尽管精神活性物质无处不在，但使大多数人口不受影响的抵抗因素可能更易于翻译。虽然责任的阻力方面与风险是对称的，但阻力方法需要在抽样（高阻力而不是高风险）和使用责任的定量指标方面进行实质性改变。这篇文章提供了一个概述和一个实用的方法来研究抵抗物质使用/成瘾，目前在美国国立卫生研究院资助的项目中实施。该项目受益于两项纵向双胞胎研究数据提供的独特机会，这两项研究分别是弗吉尼亚双胞胎青少年和行为发展研究和明尼苏达双胞胎家庭研究。所描述的方法也适用于其他精神疾病。
Illicit substance use is dangerous in both acute and chronic forms, frequently resulting in lethal poisoning, addiction, and other negative consequences. Similar to research in other psychiatric conditions, whose ultimate goal is to enable effective prevention and treatment, studies in substance use are focused on factors elevating the risk for the disorder. The rapid growth of the substance use problem despite the effort invested in fighting it, however, suggests the need in changing the research approach. Instead of attempting to identify risk factors, whose neutralization is often infeasible if not impossible, it may be more promising to systematically reverse the perspective to the factors enhancing the aspect of liability to disorder that shares the same dimension with but opposite to risk, i.e., resistance to substance use. Resistance factors, which enable the majority of the population to remain unaffected despite the ubiquity of psychoactive substances, may be more amenable to translation. While the resistance aspect of liability is symmetric to risk, the resistance approach requires substantial changes in sampling (high-resistance rather than high-risk) and using quantitative indices of liability. This article provides an overview and a practical approach to research in resistance to substance use/addiction, currently implemented in a NIH-funded project. The project benefits from unique opportunities afforded by the data originating from two longitudinal twin studies, the Virginia Twin Study of Adolescent and Behavioral Development and the Minnesota Twin Family Study. The methodology described is also applicable to other psychiatric disorders.
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DOI：
10.1016/s2215-0366(19)30048-3
发表时间：
2019-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Di Forti M;Quattrone D;Freeman TP;Tripoli G;Gayer-Anderson C;Quigley H;Rodriguez V;Jongsma HE;Ferraro L;La Cascia C;La Barbera D;Tarricone I;Berardi D;Szöke A;Arango C;Tortelli A;Velthorst E;Bernardo M;Del-Ben CM;Menezes PR;Selten JP;Jones PB;Kirkbride JB;Rutten BP;de Haan L;Sham PC;van Os J;Lewis CM;Lynskey M;Morgan C;Murray RM;EU-GEI WP2 Group
通讯作者：
EU-GEI WP2 Group
影响因子：
4.6
作者：
Hicks, Brian M.;Blonigen, Daniel M.;Mcgue, Matt
通讯作者：
Mcgue, Matt
影响因子：
0.9
作者：
Guo, G
通讯作者：
Guo, G
朝着全球酒精，烟草，大麻和可卡因的使用：WHO世界心理健康调查的发现。
影响因子：
15.8
作者：
Degenhardt, Louisa;Chiu, Wai-Tat;Sampson, Nancy;Kessler, Ronald C.;Anthony, James C.;Angermeyer, Matthias;Bruffaerts, Ronny;de Girolamo, Giovanni;Gureje, Oye;Huang, Yueqin;Karam, Aimee;Kostyuchenko, Stanislav;Lepine, Jean Pierre;Mora, Maria Elena Medina;Neumark, Yehuda;Ormel, J. Hans;Pinto-Meza, Alejandra;Posada-Villa, Jose;Stein, Dan J.;Takeshima, Tadashi;Wells, J. Elisabeth
通讯作者：
Wells, J. Elisabeth
DOI：
10.1073/pnas.1404402111
发表时间：
2014-04-22
影响因子：
11.1
作者：
Alberts, Bruce;Kirschner, Marc W.;Varmus, Harold
通讯作者：
Varmus, Harold