Microvascular dysfunction in pediatric patients with SARS-COV-2 pneumonia: report of three severe cases.
Microvascular dysfunction in pediatric patients with SARS-COV-2 pneumonia: report of three severe cases.
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DOI：
10.1016/j.mvr.2022.104312
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发表时间：
2022-05
影响因子：
3.1
通讯作者：
Donati A
中科院分区：
文献类型：
--
作者：
Bottari G;Damiani E;Confalone V;Scorcella C;Casarotta E;Gandolfo C;Stoppa F;Cecchetti C;Donati A
冠状病毒19（COVID-19）大流行影响了全球数亿人：在大多数情况下，儿童和年轻人出现了无症状或症状很少的临床症状。然而，作者已经表明，有一些类别的儿童更容易受到COVID-19感染，如新生儿或患有合并症的儿童。据我们所知，我们首次报告了三例发生COVID-19感染并需要儿科重症监护的儿科临床病例中的微血管功能障碍。我们发现，患有严重COVID-19感染的儿童舌下微循环发生改变。我们的研究结果证实了其他作者在受严重COVID-19感染影响的成年人群中观察到的大部分数据，但与之前在MIS-C临床病例中观察到的微循环改变相比具有明显的特征。然而，我们无法在我们的系列中建立微循环分析与临床或实验室参数之间的直接相关性，根据我们的经验，我们发现舌下微循环分析允许临床医生直接报告COVID-19患者的微循环功能障碍，并且它可能是监测该人群血栓形成并发症的有价值的床边技术。
The coronavirus 19 (COVID-19) pandemic has affected hundreds of millions of people worldwide: in most of cases children and young people developed asymptomatic or pauci-symptomatic clinical pictures. However authors have showed that there are some categories of childhood more vulnerable to COVID-19 infection such as newborns or children with comorbidities. We report for the first time to the best of our knowledge about microvascular dysfunction in three pediatric clinical cases who developed COVID-19 infections with need of pediatric critical care. We found that sublingual microcirculation is altered in children with severe COVID-19 infection. Our findings confirmed most of data already observed by other authors in adult population affected by severe COVID-19 infection, but with distinct characteristics than microcirculation alterations previous observed in a clinical case of MIS-C. However we cannot establish direct correlation between microcirculation analysis and clinical or laboratory parameters in our series, by our experience we have found that sublingual microcirculation analysis allow clinicians to report directly about microcirculation dysfunction in COVID-19 patients and it could be a valuable bedside technique to monitor thrombosis complication in this population.
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