Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study.
Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study.
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作者：
Boerma, EC;Mathura, KR;van der Voort, PHJ;Spronk, PE;Ince, C
正交偏振光谱（OPS）成像在临床研究中的引入阐明了微循环血流异常在脓毒症发病机制中的作用的新观点。理解和再现这些异常的过程中必不可少的是流量分数的量化方法。在与来自微循环OPS成像不同经验领域的六个研究中心的合作者的共识会议中，定义了一种简单、半透明和可重现的血流评分方式的预先资格。因此，在一组12例腹部脓毒症和新造口患者中进行了单中心前瞻性观察验证研究。以标准化的方式获得、处理和分析舌下和造口区域血管床中微循环的流动图像。我们验证了观察者内和观察者间的重现性与kappa交叉表两种类型的微血管床。在不同的微血管结构亚组中，脓毒症期间血流异常定量的评价者间和评价者内变异性的一致性和kappa系数分别>85%和>0.75。如所述，微循环流量的半定量分析在临床研究中提供了一种可重复和透明的工具，以监测和评估脓毒症期间的微循环。
The introduction of orthogonal polarization spectral (OPS) imaging in clinical research has elucidated new perspectives on the role of microcirculatory flow abnormalities in the pathogenesis of sepsis. Essential to the process of understanding and reproducing these abnormalities is the method of quantification of flow scores. In a consensus meeting with collaboraters from six research centres in different fields of experience with microcirculatory OPS imaging, premeditated qualifications for a simple, translucent and reproducible way of flow scoring were defined. Consecutively, a single-centre prospective observational validation study was performed in a group of 12 patients with an abdominal sepsis and a new stoma. Flow images of the microcirculation in vascular beds of the sublingual and stoma region were obtained, processed and analysed in a standardised way. We validated intra-observer and inter-observer reproducibility with kappa cross-tables for both types of microvascular beds. Agreement and kappa coefficients were >85% and >0.75, respectively, for interrater and intrarater variability in quantification of flow abnormalities during sepsis, in different subsets of microvascular architecture. Semi-quantitative analysis of microcirculatory flow, as described, provides a reproducible and transparent tool in clinical research to monitor and evaluate the microcirculation during sepsis.
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影响因子：
--
作者：
INCE, C;ASHRUF, JF;BRUINING, HA
通讯作者：
BRUINING, HA
影响因子：
3.3
作者：
Schwarte, LA;Fournell, A;Ince, C
通讯作者：
Ince, C
DOI：
10.1164/rccm.200109-016oc
发表时间：
2002-07-01
影响因子：
24.7
作者：
De Backer, D;Creteur, J;Vincent, JL
通讯作者：
Vincent, JL
影响因子：
5.7
作者：
Buise, MP;Ince, C;van Bommel, J
通讯作者：
van Bommel, J
DOI：
10.1186/cc3753
发表时间：
2005
期刊：
Critical care (London, England)
影响因子：
--
作者：
Ince C
通讯作者：
Ince C