Drug-resistant tuberculosis in the 1990s.
Drug-resistant tuberculosis in the 1990s.
复制标题
20世纪90年代的耐药结核病。
DOI：
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发表时间：
1995
影响因子：
24.3
通讯作者：
C. Chau
中科院分区：
文献类型：
--
作者：
W. Yew;C. Chau
在过去十年中，世界许多地方的结核病病例激增。目前在许多国家报告的高耐药结核病发病率令人震惊。最具灾难性的现象是结核分枝杆菌耐多药菌株的出现。这些微生物在美国和一些欧洲国家的医院和卫生保健机构中引起了流行病的爆发。除了移民、贫穷、酗酒和静脉注射药物滥用之外，人体免疫缺陷病毒（艾滋病毒）感染也对耐药性的流行产生了重大影响，因为在这些患者群体中，导致耐药性的一个共同因素是不遵守规定。需要进行快速药敏试验，并且迫切需要寻找新开发药物与传统二线抗结核药物联合治疗已确定的耐多药结核病的有效化疗方案。人们也在寻求其他新颖的治疗方式。应积极采取措施，防止耐药性的发展。良好的短期化疗作为初始治疗和保证依从性是最重要的组成部分。制定一个具有健全和运作适当的基础设施的国家结核病控制规划仍然是防治结核病死灰复燃和减少耐药性的最有效战略。
There has been an upsurge of tuberculosis in many parts of the world in the past decade. The high rates of drug-resistant tuberculosis currently reported in many countries are alarming. The most catastrophic phenomenon is the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. These organisms have caused epidemic outbreaks in nosocomial and health-care settings in the USA and some European countries. In addition to immigration, poverty, alcoholism and intravenous substance abuse, human immunodeficiency virus (HIV) infection has also had a significant impact on the prevalence of drug resistance, since amongst these patient groups a common factor giving rise to drug resistance is noncompliance. Rapid drug susceptibility tests are needed, and effective chemotherapy regimens with newly developed drugs in combination with traditional second-line antituberculosis agents for established multidrug-resistant tuberculosis are urgently being sought. There is also a quest for other novel modalities of therapy. Measures should be actively adopted to prevent the development of drug resistance. Well formulated short-course chemotherapy as initial treatment and ensurance of compliance are the most important components. The organization of a national tuberculosis control programme with a sound and adequately functioning infrastructure remains the most effective strategy to combat the resurgence of tuberculosis and to curtail drug resistance.
影响因子：
56.9
作者：
JACOBS, WR;BARLETTA, RG;BLOOM, BR
通讯作者：
BLOOM, BR