Repair of Bony Defect With Combination Biomaterials
Repair of Bony Defect With Combination Biomaterials
复制标题
组合生物材料修复骨缺损
DOI：
10.1097/00001665-200401000-00006
复制
发表时间：
2004
影响因子：
0.9
通讯作者：
G. Szabó
中科院分区：
文献类型：
--
作者：
N. Velich;Z. Németh;K. Hrabák;Z. Suba;G. Szabó
背景面部骨缺损的重建有多种可能性。用来填补这些缺陷的材料必须满足各种要求。其中最重要的一点是，它们必须在重建过程中转化为自体骨组织。AIMA报告了两例患者应用不同的骨替代材料修复大段骨缺损的远期效果。患者和方法在一个病例中，纤维粘液瘤切除后用磷酸三钙进行了隆起术。在第二个病例中，Gorlin-Goltz综合征患者下颌骨的三个大的囊性病变被填充了磷酸三钙，磷酸三钙和浓缩的血小板的混合物，或藻类来源的羟基磷灰石。每隔6个月通过临床、放射学(正位X线片、二维和三维计算机断层摄影)和组织学方法检查骨化过程。结果术后1年，所有病例隆起部位均为质地良好的硬组织。在给定的成像程序下，很难区分原始骨骼和填充了骨替代材料的区域。三维计算机断层图像显示，新骨的轮廓和质量符合生理和解剖条件。组织学检查可见骨替代材料的改建。这些病例中应用的骨替代材料完全满足了向骨转化(改建)的要求。当使用磷酸三钙和浓缩血小板的混合物时，重塑速度似乎最快。
BackgroundNumerous possibilities are available for the reconstruction of facial bone defects. The materials used to fill such defects must satisfy various requirements. One of the most important is that they must undergo transformation into autologous bone tissue in the process of remodeling. AimA report is given of the long-term results of augmentations of large bone defects performed with different bone-substitute materials in two patients. Patients and methodsIn one case, augmentation was carried out with &bgr;-tricalcium phosphate after the removal of a fibromyxoma. In the second case, three large cystic lesions in the mandible of a patient with Gorlin-Goltz syndrome were filled with &bgr;-tricalcium phosphate, with a mixture of &bgr;-tricalcium phosphate and platelet concentrate, or with hydroxyapatite of algal origin. The process of ossification was checked at 6-month intervals by means of clinical, radiologic (orthopantomograms and two-dimensional and three-dimensional computer tomograms), and histologic methods. ResultsAt 1 year after the intervention, the site of the augmentation was in all cases occupied by hard tissue of good quality. With the given imaging procedures, it was difficult to distinguish between the original bone and the region filled with bone-substitute material. The three-dimensional computer tomogram images indicated that the contours and quality of the new bone corresponded with the physiologic and anatomical conditions. The histologic examinations show the remodeling of the bone-substitute materials. DiscussionThe bone-substitute materials applied in these cases fully satisfied the demands of transformation into bone (remodeling). The speed of remodeling seemed to be the fastest when the mixture of &bgr;-tricalcium phosphate and platelet concentrate was used.
骨中的肽和生长调节因子。
DOI：
--
发表时间：
1994
期刊：
Rheumatic diseases clinics of North America
影响因子：
--
作者：
Mundy,GR
通讯作者：
Mundy,GR
骨形态发生蛋白和其他生长因子对骨形成的调节。
影响因子：
4.2
作者：
Mundy,GR
通讯作者：
Mundy,GR