CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides.
CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides.
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DOI：
10.3389/fimmu.2018.00548
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发表时间：
2018
影响因子：
7.3
通讯作者：
Ishizu A
中科院分区：
文献类型：
--
作者：
Nishioka Y;Masuda S;Tomaru U;Ishizu A
NKT细胞属于一个独特的T细胞亚群，它识别主要组织相容性复合体I类分子提出的疏水抗原，如CD1d。由于受抗原刺激的NKT细胞可以通过立即产生大量细胞因子来激活或抑制其他免疫活性细胞，因此它们被认为是免疫调节剂。CD1d限制性NKT细胞分为I型和II型。CD1d限制性I型NKT细胞表达不变T细胞受体(TCR)，并与脂类抗原反应，包括海绵糖脂α-半乳糖神经酰胺。相反，CD1d限制性的II型NKT细胞通过其不同的TCR识别多种抗原，包括糖脂、磷脂和疏水肽。在这篇综述中，我们特别关注CD1d限制性的II型NKT细胞，它们识别由CD1d呈递的内源性疏水肽。以前的研究表明，CD1d限制性的I型NKT细胞通常作为促炎细胞发挥作用，但有时也发挥抗炎细胞的作用。研究还表明，CD1d限制性的II型NKT细胞与CD1d限制性的I型NKT细胞发挥相反的作用；因此，它们的功能取决于情况而定的抗炎或促炎细胞。与此相一致，识别II型胶原肽的CD1d限制性II型NKT细胞已被证明在不同的炎症诱导模型中发挥抗炎细胞的作用，而与固醇载体蛋白2肽反应的促炎性CD1d限制性II型NKT细胞已被证明参与大鼠小血管炎的发生。
NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress other immunocompetent cells through an immediate production of a large amount of cytokines, they are regarded as immunological modulators. CD1d-restricted NKT cells are classified into two subsets, namely, type I and type II. CD1d-restricted type I NKT cells express invariant T cell receptors (TCRs) and react with lipid antigens, including the marine sponge-derived glycolipid α-galactosylceramide. On the contrary, CD1d-restricted type II NKT cells recognize a wide variety of antigens, including glycolipids, phospholipids, and hydrophobic peptides, by their diverse TCRs. In this review, we focus particularly on CD1d-restricted type II NKT cells that recognize endogenous hydrophobic peptides presented by CD1d. Previous studies have demonstrated that CD1d-restricted type I NKT cells usually act as pro-inflammatory cells but sometimes behave as anti-inflammatory cells. It has been also demonstrated that CD1d-restricted type II NKT cells play opposite roles to CD1d-restricted type I NKT cells; thus, they function as anti-inflammatory or pro-inflammatory cells depending on the situation. In line with this, CD1d-restricted type II NKT cells that recognize type II collagen peptide have been demonstrated to act as anti-inflammatory cells in diverse inflammation-induction models in mice, whereas pro-inflammatory CD1d-restricted type II NKT cells reactive with sterol carrier protein 2 peptide have been demonstrated to be involved in the development of small vessel vasculitis in rats.
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影响因子：
4.4
作者：
Griseri, T;Beaudoin, L;Lehuen, AS
通讯作者：
Lehuen, AS
影响因子：
56.9
作者：
CASTANO, AR;TANGRI, S;PETERSON, PA
通讯作者：
PETERSON, PA
影响因子：
15.9
作者：
Halder, Ramesh C.;Aguilera, Carlos;Kumar, Vipin
通讯作者：
Kumar, Vipin
通过靶向独特的无引起的CD1D反应T细胞群体对硫化物的反应性，预防自身免疫性。
影响因子：
15.3
作者：
Jahng, A;Maricic, I;Aguilera, C;Cardell, S;Halder, RC;Kumar, V
通讯作者：
Kumar, V
DOI：
10.4049/jimmunol.1601399
发表时间：
2017-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dhodapkar MV;Kumar V
通讯作者：
Kumar V