Cognitive stimulation and cognitive and functional decline in Alzheimer's disease: the cache county dementia progression study.
Cognitive stimulation and cognitive and functional decline in Alzheimer's disease: the cache county dementia progression study.
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阿尔茨海默氏病的认知刺激以及认知和功能下降：卡什县痴呆进展研究。
DOI：
10.1093/geronb/gbr023
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tschanz,JoannT
中科院分区：
文献类型：
--
作者：
Treiber,KatherineA;Carlson,MichelleC;Corcoran,Chris;Norton,MariaC;Breitner,JohnCS;Piercy,KathleenW;Deberard,MichaelScott;Stein,David;Foley,Beth;Welsh-Bohmer,KathleenA;Frye,Amber;Lyketsos,ConstantineG;Tschanz,JoannT
目的探讨认知刺激活动与阿尔茨海默病(AD)认知功能衰退之间的关系。方法187名AD患者(65%为女性)确诊后每半年进行一次平均2.7年(SD=0.4)的跟踪调查。平均年龄84.6岁(SD=5.8)，平均受教育13.2岁(SD=2.9)。照顾者通过生活方式活动问卷列举了具有认知刺激作用的休闲活动。认知功能评定采用简易智力状态检查量表，功能能力评定采用临床痴呆评定量表。线性混合模型测试了刺激活动与每种结果随时间变化之间的关联。协变量为人口统计学因素、发病前估计智商、APOEϵ4等位基因的存在或缺失、痴呆病程、体力活动水平和一般健康状况。这一数字在最后一次访问时下降到2.4(2.0)。在预测认知功能减退率(p=.02)和总体功能能力(p=.006)方面，痴呆症病程和活动次数之间存在统计学交互作用。
ObjectivesTo examine the association of engagement in cognitively stimulating activities with cognitive and functional decline in a population-based sample of incident Alzheimer's disease (AD).MethodAfter diagnosis, 187 participants (65% females) were followed semiannually for a mean 2.7 (SD= 0.4) years. Mean age and education were 84.6 (SD= 5.8) and 13.2 (SD= 2.9) years. Caregivers enumerated cognitively stimulating leisure activities via the Lifestyle Activities Questionnaire. Cognition was assessed using the Mini-Mental State Examination and functional ability via the Clinical Dementia Rating sum of boxes. Linear mixed models tested the association between stimulating activities and change over time in each outcome. Covariates were demographic factors, estimated premorbid IQ, presence/absence of theAPOEϵ4 allele, duration of dementia, level of physical activity, and general health.ResultsAt initial assessment, 87% of participants were engaged in one or more stimulating activities, with mean (SD) activities = 4.0 (3.0). This number declined to 2.4 (2.0) at the final visit. There was a statistical interaction between dementia duration and number of activities in predicting rate of cognitive decline (p= .02) and overall functional ability (p= .006).DiscussionActive involvement in cognitively stimulating pursuits may be beneficial for persons with AD.
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影响因子：
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作者：
P. Rakic
通讯作者：
P. Rakic
影响因子：
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作者：
Scarmeas, N;Zarahn, E;Stern, Y
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修改后的小型精神状态检查的改编：人口影响和规范数据分析：卡什县研究。
DOI：
--
发表时间：
2002
期刊：
Neuropsychiatry, neuropsychology, and behavioral neurology.
影响因子：
--
作者：
Tschanz,JoAnnT;Welsh-Bohmer,KathleenA;Plassman,BrendaL;Norton,MariaC;Wyse,BonitaW;Breitner,JohnCS;CacheCountyStudyGroup
通讯作者：
CacheCountyStudyGroup
影响因子：
120.7
作者：
Wilson, RS;de Leon, CFM;Bennett, DA
通讯作者：
Bennett, DA
影响因子：
120.7
作者：
Weuve, J;Kang, JH;Grodstein, F
通讯作者：
Grodstein, F