An overview of prognostic factors for long-term survivors of breast cancer.
An overview of prognostic factors for long-term survivors of breast cancer.
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DOI：
10.1007/s10549-007-9556-1
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发表时间：
2008-02
影响因子：
3.8
通讯作者：
Coebergh, Jan Willem W.
中科院分区：
文献类型：
--
作者：
Soerjomataram, Isabelle;Louwman, Marieke W. J.;Ribot, Jacques G.;Roukema, Jan A.;Coebergh, Jan Willem W.
大量研究探讨了乳腺癌患者生存的预后因素，但专门针对 10 年以上幸存者的研究相对较少。根据以下纳入标准对 1995 年至 2006 年 PubMed 数据库进行了审查：中位/平均随访时间至少 10 年；已知总体生存率和/或疾病特异性生存率；以及报告的相对风险和统计概率值。此外，我们还使用了长期存在的埃因霍温癌症登记处的数据来说明各种预后因素所表明的生存概率。 10 年乳腺癌幸存者的 5 年相对生存率为 90%。肿瘤大小、淋巴结状态和分级仍然是长期生存最重要的预后因素，尽管它们的作用随着时间的推移而减弱。大多数研究都同意所有或部分乳腺癌患者（淋巴结阳性或阴性）的 MI（有丝分裂指数）、LVI（淋巴血管侵犯）、Her2 阳性、基因谱和合并症的长期预后价值。年龄、社会经济状况、组织学类型、BRCA 和 p53 突变的作用是混合的，在校正更强的预测因素后往往会降低，从而限制了它们的临床价值。局部和区域复发、转移和继发癌症可能会严重损害长期生存。健康的生活方式始终与较低的总体死亡率相关。传统预后因素的影响长期持续，而最近的因素需要进一步随访。存活至少 10 年的乳腺癌患者的预后良好，并且随着时间的推移而增加。通过早期检测、更有效的现代治疗和更健康的生活方式可以提高长期生存率。
Numerous studies have examined prognostic factors for survival of breast cancer patients, but relatively few have dealt specifically with 10+-year survivors. A review of the PubMed database from 1995 to 2006 was undertaken with the following inclusion criteria: median/mean follow-up time at least 10 years; overall survival and/or disease-specific survival known; and relative risk and statistical probability values reported. In addition, we used data from the long-standing Eindhoven Cancer Registry to illustrate survival probability as indicated by various prognostic factors. 10-year breast cancer survivors showed 90% 5-year relative survival. Tumor size, nodal status and grade remained the most important prognostic factors for long-term survival, although their role decreased over time. Most studies agreed on the long-term prognostic values of MI (mitotic index), LVI (lymphovascular invasion), Her2-positivity, gene profiling and comorbidity for either all or a subgroup of breast cancer patients (node-positive or negative). The roles of age, socioeconomic status, histological type, BRCA and p53 mutation were mixed, often decreasing after correction for stronger prognosticators, thus limiting their clinical value. Local and regional recurrence, metastases and second cancer may substantially impair long-term survival. Healthy lifestyle was consistently related to lower overall mortality. Effects of traditional prognostic factors persist in the long term and more recent factors need further follow-up. The prognosis for breast cancer patients who have survived at least 10 years is favourable and increases over time. Improved long-term survival can be achieved by earlier detection, more effective modern therapy and healthier lifestyle.
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影响因子：
6.4
作者：
Bouchardy, Christine;Verkooijen, Helena M.;Fioretta, Gerald
通讯作者：
Fioretta, Gerald
影响因子：
50.5
作者：
Berclaz, G;Li, S;International Breast Cancer Study Grp
通讯作者：
International Breast Cancer Study Grp
影响因子：
8.4
作者：
Ernst, MF;Voogd, AC;Roukema, JA
通讯作者：
Roukema, JA
影响因子：
8.4
作者：
D'Eredita, G;Giardina, C;Ferrarese, F
通讯作者：
Ferrarese, F
影响因子：
45.3
作者：
Chia, SK;Speers, CH;Olivotto, IA
通讯作者：
Olivotto, IA