Membranes: a meeting point for lipids, proteins and therapies.
Membranes: a meeting point for lipids, proteins and therapies.
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DOI：
10.1111/j.1582-4934.2008.00281.x
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发表时间：
2008-06
影响因子：
5.3
通讯作者：
Barceló-Coblijn G
中科院分区：
文献类型：
--
作者：
Escribá PV;González-Ros JM;Goñi FM;Kinnunen PK;Vigh L;Sánchez-Magraner L;Fernández AM;Busquets X;Horváth I;Barceló-Coblijn G
膜构成脂质和蛋白质的交汇点。它们不仅定义了细胞和胞质细胞器的实体，而且还显示了以前仅归因于蛋白质活性的各种重要功能。事实上，脂质通常被认为仅仅是膜蛋白短暂或永久结合的支持物，同时充当选择性细胞/细胞器屏障。然而，越来越多的证据表明，脂质本身调节许多膜蛋白的位置和活性，以及定义作为相互作用的信号蛋白的时空平台的膜微区。膜脂在脂双层的分裂和融合中起着至关重要的作用，并且它们还充当控制环境或生理条件的传感器。脂质和脂质结构作为信使或信号转导调节剂直接参与。此外，它们的改变与许多疾病的发展有关。蛋白质与膜的相互作用主要是通过脂质的翻译后修饰和共翻译修饰实现的，膜蛋白与脂质之间的相互作用主要包括静电相互作用、疏水相互作用、货车范德华力和氢键。本文从分子生物学的角度综述了这些相互作用及其对细胞生理活性、人类疾病病因学和临床药物设计的影响。事实上，脂质对蛋白质功能的影响反映在使用这些分子种类作为针对癌症、肥胖症、神经退行性疾病、心血管病理学和其他疾病的疗法的靶点的可能性中，使用称为膜脂质疗法的新方法。
Membranes constitute a meeting point for lipids and proteins. Not only do they define the entity of cells and cytosolic organelles but they also display a wide variety of important functions previously ascribed to the activity of proteins alone. Indeed, lipids have commonly been considered a mere support for the transient or permanent association of membrane proteins, while acting as a selective cell/organelle barrier. However, mounting evidence demonstrates that lipids themselves regulate the location and activity of many membrane proteins, as well as defining membrane microdomains that serve as spatio-temporal platforms for interacting signalling proteins. Membrane lipids are crucial in the fission and fusion of lipid bilayers and they also act as sensors to control environmental or physiological conditions. Lipids and lipid structures participate directly as messengers or regulators of signal transduction. Moreover, their alteration has been associated with the development of numerous diseases. Proteins can interact with membranes through lipid co-/post-translational modifications, and electrostatic and hydrophobic interactions, van der Waals forces and hydrogen bonding are all involved in the associations among membrane proteins and lipids. The present study reviews these interactions from the molecular and biomedical point of view, and the effects of their modulation on the physiological activity of cells, the aetiology of human diseases and the design of clinical drugs. In fact, the influence of lipids on protein function is reflected in the possibility to use these molecular species as targets for therapies against cancer, obesity, neurodegenerative disorders, cardiovascular pathologies and other diseases, using a new approach called membrane-lipid therapy.
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影响因子：
4.7
作者：
Bijur, GN;Jope, RS
通讯作者：
Jope, RS
影响因子：
5.7
作者：
Belrhali, H;Nollert, P;Pebay-Peyroula, E
通讯作者：
Pebay-Peyroula, E
影响因子：
2.9
作者：
BLANTON, MP;WANG, HH
通讯作者：
WANG, HH
影响因子：
56.9
作者：
Boyartchuk, VL;Ashby, MN;Rine, J
通讯作者：
Rine, J
影响因子：
56.9
作者：
ANANTHAN, J;GOLDBERG, AL;VOELLMY, R
通讯作者：
VOELLMY, R