Whole blood for blood loss: hemostatic resuscitation in damage control.
Whole blood for blood loss: hemostatic resuscitation in damage control.
复制标题
DOI：
10.25100/cm.v51i4.4511
复制
发表时间：
2020-12-30
期刊：
影响因子：
--
通讯作者：
Puyana JC
中科院分区：
文献类型：
--
作者：
Salamea-Molina JC;Himmler AN;Valencia-Angel LI;Ordoñez CA;Parra MW;Caicedo Y;Guzmán-Rodríguez M;Orlas C;Granados M;Macia C;García A;Serna JJ;Badiel M;Puyana JC
失血性休克及其并发症是创伤患者死亡的主要原因。失血性休克的管理使用损害控制复苏策略已被证明可以降低死亡率和改善患者的预后。损伤控制复苏的一个组成部分是止血复苏，它涉及到用填充红细胞、新鲜冷冻血浆、低温沉淀和血小板等成分以1:1:1:1的比例替换丢失的血容量。然而，这一战略并不适用于拉丁美洲和全世界其他低收入和中等收入国家的许多地区，因为这些地区缺乏装备良好的血库，血液制品供应不足。为了克服这些障碍，我们建议在失血患者中使用冷新鲜全血进行止血复苏。厄瓜多尔6年多的经验表明，与使用血液成分复苏相比，使用冷新鲜全血复苏具有相似的结果和相似的安全性。与成分疗法相比，全血疗法具有许多优势，包括但不限于按成分的生理比例输血，便于运输和输血，向患者输注抗凝剂和添加剂的量较少，以及接触较少的献血者。全血是一种具有重新出现潜力的工具，可以在民用创伤中心实施，效果最佳，技术需求较少。
Hemorrhagic shock and its complications are a major cause of death among trauma patients. The management of hemorrhagic shock using a damage control resuscitation strategy has been shown to decrease mortality and improve patient outcomes. One of the components of damage control resuscitation is hemostatic resuscitation, which involves the replacement of lost blood volume with components such as packed red blood cells, fresh frozen plasma, cryoprecipitate, and platelets in a 1:1:1:1 ratio. However, this is a strategy that is not applicable in many parts of Latin America and other low-and-middle-income countries throughout the world, where there is a lack of well-equipped blood banks and an insufficient availability of blood products. To overcome these barriers, we propose the use of cold fresh whole blood for hemostatic resuscitation in exsanguinating patients. Over 6 years of experience in Ecuador has shown that resuscitation with cold fresh whole blood has similar outcomes and a similar safety profile compared to resuscitation with hemocomponents. Whole blood confers many advantages over component therapy including, but not limited to the transfusion of blood with a physiologic ratio of components, ease of transport and transfusion, less volume of anticoagulants and additives transfused to the patient, and exposure to fewer donors. Whole blood is a tool with reemerging potential that can be implemented in civilian trauma centers with optimal results and less technical demand.
登录
查看更多内容
DOI：
10.1097/ta.0b013e318208f99b
发表时间：
2011-02-01
影响因子：
--
作者：
Ley, Eric J.;Clond, Morgan A.;Salim, Ali
通讯作者：
Salim, Ali
影响因子：
9
作者：
Cotton, Bryan A.;Podbielski, Jeanette;Holcomb, John B.
通讯作者：
Holcomb, John B.
影响因子：
3.4
作者：
Ditzel, Ricky Michael, Jr.;Anderson, Justin Lee;Siegler, Jeffrey
通讯作者：
Siegler, Jeffrey
影响因子：
7.1
作者：
Kushimoto S;Kudo D;Kawazoe Y
通讯作者：
Kawazoe Y
DOI：
10.1097/ta.0b013e3182826e13
发表时间：
2013-05
期刊：
The journal of trauma and acute care surgery
影响因子：
--
作者：
Kasotakis G;Sideris A;Yang Y;de Moya M;Alam H;King DR;Tompkins R;Velmahos G;Inflammation and Host Response to Injury Investigators
通讯作者：
Inflammation and Host Response to Injury Investigators