Heat shock protein 90 in plants: molecular mechanisms and roles in stress responses.
Heat shock protein 90 in plants: molecular mechanisms and roles in stress responses.
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植物中的热休克蛋白 90：分子机制及其在应激反应中的作用
DOI：
10.3390/ijms131215706
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发表时间：
2012-11-23
影响因子：
5.6
通讯作者：
Ma YZ
中科院分区：
文献类型：
--
作者：
Xu ZS;Li ZY;Chen Y;Chen M;Li LC;Ma YZ
热休克蛋白90（Heat shock protein 90，Hsp90）家族介导应激信号传导，在调控人体细胞正常生长和促进肿瘤细胞的发生发展中发挥重要作用。热休克蛋白90已成为当前细胞免疫、信号转导和抗肿瘤研究的重要课题。对植物中Hsp90 s生理功能的研究起步较晚，而对动物和真菌中Hsp90 s生理功能的研究起步较晚。近年来，对植物HSP90的复杂作用机制的研究取得了重要进展，包括ATP酶偶联的构象变化和与辅伴侣蛋白的相互作用。多种信号蛋白与HSP90相互作用。近年来的研究表明，植物热休克蛋白90在植物发育、环境胁迫反应和抗病虫害等方面具有重要作用。本文根据系统发育关系、基因结构和生物学功能将植物HSP90家族分为三大类。本文综述了热休克蛋白90的分子功能，并对近年来植物热休克蛋白90的研究进展进行了系统的综述。
The heat shock protein 90 (Hsp90) family mediates stress signal transduction, and plays important roles in the control of normal growth of human cells and in promoting development of tumor cells. Hsp90s have become a currently important subject in cellular immunity, signal transduction, and anti-cancer research. Studies on the physiological functions of Hsp90s began much later in plants than in animals and fungi. Significant progress has been made in understanding complex mechanisms of HSP90s in plants, including ATPase-coupled conformational changes and interactions with cochaperone proteins. A wide range of signaling proteins interact with HSP90s. Recent studies revealed that plant Hsp90s are important in plant development, environmental stress response, and disease and pest resistance. In this study, the plant HSP90 family was classified into three clusters on the basis of phylogenetic relationships, gene structure, and biological functions. We discuss the molecular functions of Hsp90s, and systematically review recent progress of Hsp90 research in plants.
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影响因子：
5.1
作者：
Aviezer-Hagai, Keren;Skovorodnikova, Julia;Breiman, Adina
通讯作者：
Breiman, Adina
影响因子：
11.4
作者：
Hubert, DA;Tornero, P;Dangl, JL
通讯作者：
Dangl, JL
影响因子：
4.5
作者：
Echeverría PC;Forafonov F;Pandey DP;Mühlebach G;Picard D
通讯作者：
Picard D
影响因子：
3.4
作者：
Dmochewitz L;Lillich M;Kaiser E;Jennings LD;Lang AE;Buchner J;Fischer G;Aktories K;Collier RJ;Barth H
通讯作者：
Barth H
影响因子：
16.8
作者：
Hessling, Martin;Richter, Klaus;Buchner, Johannes
通讯作者：
Buchner, Johannes