Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel.
Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel.
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DOI：
10.1016/j.heares.2011.05.010
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发表时间：
2011-08
期刊：
影响因子：
2.8
通讯作者：
Bao, Jianxin
中科院分区：
文献类型：
--
作者：
Lei, Debin;Gao, Xia;Perez, Philip;Ohlemiller, Kevin K.;Chen, Chien-Chang;Campbell, Kevin P.;Hood, Aizhen Yang;Bao, Jianxin
Loss of spiral ganglion neurons is a major cause of age-related hearing loss (presbycusis). Despite being the third most prevalent condition afflicting elderly persons, there are no known medications to prevent presbycusis. Because calcium signaling has long been implicated in age-related neuronal death, we investigated T-type calcium channels. This family is comprised of three members (Cav3.1, Cav3.2, and Cav3.3), based on their respective main pore-forming alpha subunits: α1G, α1H, and α1I. In the present study, we report a significant delay of age-related loss of cochlear function and preservation of spiral ganglion neurons in α1H null and heterozygous mice, clearly demonstrating an important role for Cav3.2 in age-related neuronal loss. Furthermore, we show that anticonvulsant drugs from a family of T-type calcium channel blockers can significantly preserve spiral ganglion neurons during aging. To our knowledge, this is the first report of drugs capable of diminishing age-related loss of spiral ganglion neurons.
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影响因子：
2.9
作者：
Ohlemiller, Kevin K.
通讯作者：
Ohlemiller, Kevin K.
影响因子：
2.2
作者：
Barton, ME;Klein, BD;White, HS
通讯作者：
White, HS
影响因子：
2.5
作者：
Nie, Liping;Zhu, Jun;Yamoah, Ebenezer N.
通讯作者：
Yamoah, Ebenezer N.
影响因子：
2.8
作者：
Shen, Haiyan;Zhang, Baoping;Bao, Jianxin
通讯作者：
Bao, Jianxin
周围神经元中Ca2+稳态的年龄依赖性变化：对功能变化的影响。
影响因子：
7.8
作者：
Buchholz, John N;Behringer, Erik J;Pottorf, William J;Pearce, William J;Vanterpool, Conwin K
通讯作者：
Vanterpool, Conwin K