Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma.
Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma.
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DOI：
10.1038/bjc.2014.71
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发表时间：
2014-04-02
影响因子：
8.8
通讯作者：
Chouaib, S.
中科院分区：
文献类型：
--
作者：
Saroufim, A.;Messai, Y.;Hasmim, M.;Rioux, N.;Iacovelli, R.;Verhoest, G.;Bensalah, K.;Patard, J-J;Albiges, L.;Azzarone, B.;Escudier, B.;Chouaib, S.
血管生成对于肿瘤生长和转移是必不可少的。关于透明细胞肾细胞癌（ccRCC）中使用内皮标志物CD 105（分化分子簇105）的微血管密度（MVD）是否与预后相关，存在相互矛盾的报道。最近，CD 105已被描述为RCC癌症干细胞标志物。共分析了102例ccRCC。对代表性肿瘤切片进行CD 105染色。通过MVD定量血管（内皮CD 105）。免疫组织化学分析检测到阳性（如果存在）或阴性（如果不存在）CD 105肿瘤染色。采用Kaplan-Meier法、t检验和考克斯比例风险模型对该回顾性研究进行评价。内皮细胞CD 105（MVD）的表达与核分级（P<0.001）、肿瘤分期（P<0.001）和Leibovitch评分（P<0.001）呈负相关，而肿瘤细胞CD 105的表达与上述三个临床病理因素呈正相关（P<0.001）。在多变量分析中，发现肿瘤CD 105是总生存率差的独立预测因子（P=0.002）。我们首次证明肿瘤CD 105是治愈性切除术后ccRCC患者死亡风险和不良预后的独立预测标志物。
Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105 has been described as a RCC cancer stem cell marker. A total of 102 ccRCC were analysed. Representative tumour sections were stained for CD105. Vascularity (endothelial CD105) was quantified by MVD. The immunohistochemistry analysis detected positive (if present) or negative (if absent) CD105 tumoral staining. This retrospective population-based study was evaluated using Kaplan–Meier method, t-test and Cox proportional hazard model. We found that the expression of endothelial CD105 (MVD) negatively correlated with nuclear grade (P<0.001), tumour stage (P<0.001) and Leibovitch score (P<0.001), whereas the expression of tumoral CD105 positively correlated with these three clinicopathological factors (P<0.001). In multivariate analysis, tumoral CD105 was found to be an independent predictor of poor overall survival (P=0.002). We have shown for the first time that tumoral CD105 is an independent predictive marker for death risk and unfavourable prognosis in patients with ccRCC after curative resection.
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影响因子：
4.8
作者：
Bussolati, Benedetta;Bruno, Stefania;Camussi, Giovanni
通讯作者：
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Vermeulen, PB;Gasparini, G;Dirix, LY
通讯作者：
Dirix, LY