Sex chromosome complement and sex steroid signaling underlie sex differences in immunity to respiratory virus infection.
Sex chromosome complement and sex steroid signaling underlie sex differences in immunity to respiratory virus infection.
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DOI：
10.3389/fphar.2023.1150282
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
流行病学研究表明，人类呼吸道病毒感染的发病率和发病率存在性别差异，这些观察结果通常与免疫应答的质量或程度的性别差异相关。在呼吸道病毒感染的动物模型中也观察到免疫和发病率的性别差异，表明特异性免疫机制的差异优势。新兴的研究表明，免疫细胞转录组，表观基因组和蛋白质组的内在性别差异，可能会调节人类免疫时，受到病毒感染的挑战。在这里，我们强调了最近的研究性类固醇和X染色体补体在免疫细胞中的作用，并描述了这些发现如何提供呼吸道病毒感染期间免疫的见解。我们专注于先天性和适应性免疫细胞的雄激素和雌激素受体的调节，以及与逃避X染色体失活的倾向的基因。对这些途径的更深入的机制知识将有助于我们了解对地方性或大流行性呼吸道病原体（如流感病毒、呼吸道合胞病毒和致病性冠状病毒）的免疫力通常存在显著的性别差异。
Epidemiological studies have revealed sex differences in the incidence and morbidity of respiratory virus infection in the human population, and often these observations are correlated with sex differences in the quality or magnitude of the immune response. Sex differences in immunity and morbidity also are observed in animal models of respiratory virus infection, suggesting differential dominance of specific immune mechanisms. Emerging research shows intrinsic sex differences in immune cell transcriptomes, epigenomes, and proteomes that may regulate human immunity when challenged by viral infection. Here, we highlight recent research into the role(s) of sex steroids and X chromosome complement in immune cells and describe how these findings provide insight into immunity during respiratory virus infection. We focus on the regulation of innate and adaptive immune cells by receptors for androgen and estrogens, as well as genes with a propensity to escape X chromosome inactivation. A deeper mechanistic knowledge of these pathways will help us to understand the often significant sex differences in immunity to endemic or pandemic respiratory pathogens such as influenza viruses, respiratory syncytial viruses and pathogenic coronaviruses.
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DOI：
10.4049/jimmunol.1601896
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Channappanavar R;Fett C;Mack M;Ten Eyck PP;Meyerholz DK;Perlman S
通讯作者：
Perlman S
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
DOI：
10.1073/pnas.1805268115
发表时间：
2018-12-04
影响因子：
11.1
作者：
Fink, Ashley L.;Engle, Kyrra;Klein, Sabra L.
通讯作者：
Klein, Sabra L.
影响因子：
--
作者：
Abramowitz, Lara K;Olivier-Van Stichelen, Stephanie;Hanover, John A
通讯作者：
Hanover, John A
影响因子：
39.3
作者：
Hou Y;Zhou Y;Gack MU;Lathia JD;Kallianpur A;Mehra R;Chan TA;Jung JU;Jehi L;Eng C;Cheng F
通讯作者：
Cheng F