Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.
Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.
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DOI：
10.3390/cancers14010035
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发表时间：
2021-12-22
期刊：
影响因子：
5.2
通讯作者：
Incerti S
中科院分区：
文献类型：
--
作者：
Kyriakou I;Sakata D;Tran HN;Perrot Y;Shin WG;Lampe N;Zein S;Bordage MC;Guatelli S;Villagrasa C;Emfietzoglou D;Incerti S
简要介绍了模拟生物相关物质中电离辐射输运的方法。重点是Geant 4-DNA的物理，化学和生物学模型，使机械放射生物学建模在细胞和DNA水平，重要的是提高现有的和新的放射治疗方式治疗癌症的疗效。Geant 4-DNA低能扩展的Geant 4蒙特卡罗（MC）工具包是一个不断发展的MC模拟代码，允许细胞放射生物学效应的机制研究。Geant 4-DNA考虑了电离辐射（以X和γ射线光子，电子和β±射线，强子，α粒子和一组较重离子的形式）在活细胞中作用的物理，化学和生物学阶段，用于各种应用，从预测放射治疗结果到地球和太空中的辐射防护。在这项工作中，我们提供了一个简短而简洁的概述，迄今为止已经取得的进展，有关不同的物理，物理化学，化学和生物模型实施到Geant 4-DNA，突出了最新的发展。具体来说，“dnadamage 1”和“molecularDNA”应用程序首次在开源平台内实现了对早期DNA损伤的定量预测，包括单链断裂（SSB），双链断裂（DSB）以及从核苷酸水平到整个基因组的不同DNA结构的更复杂的簇状病变。这些发展是批判性的介绍和讨论沿着与关键的基准测试结果。Geant 4-DNA工具包通过其不同的模型和功能集，提供了阐明辐射质量或不同电离辐射的相对生物有效性（RBE）问题的独特能力，这些电离辐射强调了几乎整个辐射模式谱，从外部高能强子束到用于近距离放射治疗源和放射性药物的内部低能伽马和β发射器，分别
A brief description of the methodologies to simulate ionizing radiation transport in biologically relevant matter is presented. Emphasis is given to the physical, chemical, and biological models of Geant4-DNA that enable mechanistic radiobiological modeling at the cellular and DNA level, important to improve the efficacy of existing and novel radiotherapeutic modalities for the treatment of cancer. The Geant4-DNA low energy extension of the Geant4 Monte Carlo (MC) toolkit is a continuously evolving MC simulation code permitting mechanistic studies of cellular radiobiological effects. Geant4-DNA considers the physical, chemical, and biological stages of the action of ionizing radiation (in the form of x- and γ-ray photons, electrons and β±-rays, hadrons, α-particles, and a set of heavier ions) in living cells towards a variety of applications ranging from predicting radiotherapy outcomes to radiation protection both on earth and in space. In this work, we provide a brief, yet concise, overview of the progress that has been achieved so far concerning the different physical, physicochemical, chemical, and biological models implemented into Geant4-DNA, highlighting the latest developments. Specifically, the “dnadamage1” and “molecularDNA” applications which enable, for the first time within an open-source platform, quantitative predictions of early DNA damage in terms of single-strand-breaks (SSBs), double-strand-breaks (DSBs), and more complex clustered lesions for different DNA structures ranging from the nucleotide level to the entire genome. These developments are critically presented and discussed along with key benchmarking results. The Geant4-DNA toolkit, through its different set of models and functionalities, offers unique capabilities for elucidating the problem of radiation quality or the relative biological effectiveness (RBE) of different ionizing radiations which underlines nearly the whole spectrum of radiotherapeutic modalities, from external high-energy hadron beams to internal low-energy gamma and beta emitters that are used in brachytherapy sources and radiopharmaceuticals, respectively.
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影响因子：
3.8
作者：
Arce P;Bolst D;Bordage MC;Brown JMC;Cirrone P;Cortés-Giraldo MA;Cutajar D;Cuttone G;Desorgher L;Dondero P;Dotti A;Faddegon B;Fedon C;Guatelli S;Incerti S;Ivanchenko V;Konstantinov D;Kyriakou I;Latyshev G;Le A;Mancini-Terracciano C;Maire M;Mantero A;Novak M;Omachi C;Pandola L;Perales A;Perrot Y;Petringa G;Quesada JM;Ramos-Méndez J;Romano F;Rosenfeld AB;Sarmiento LG;Sakata D;Sasaki T;Sechopoulos I;Simpson EC;Toshito T;Wright DH
通讯作者：
Wright DH
影响因子：
2.6
作者：
Champion, Christophe;Le Loirec, Cindy;Stosic, Borko
通讯作者：
Stosic, Borko
影响因子：
3.8
作者：
Chatzipapas KP;Papadimitroulas P;Obeidat M;McConnell KA;Kirby N;Loudos G;Papanikolaou N;Kagadis GC
通讯作者：
Kagadis GC
DOI：
10.1016/0168-583x(95)00349-5
发表时间：
1995-05-01
影响因子：
1.3
作者：
BARO, J;SEMPAU, J;SALVAT, F
通讯作者：
SALVAT, F
DOI：
10.1016/j.nima.2016.06.125
发表时间：
2016-11-01
影响因子：
1.4
作者：
Allison, J.;Amako, K.;Yoshida, H.
通讯作者：
Yoshida, H.