Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial
Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial
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低温灌注对白内障合并葡萄膜炎患者超声乳化术的影响：一项随机试验
DOI：
10.1186/s12886-020-01507-9
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发表时间：
2020-06
影响因子：
2
通讯作者：
Ke Hu
中科院分区：
文献类型：
--
作者：
Lu Jiang;Wenjuan Wan;Yan Xun;Liang Xiong;Binge Wu;Yongguo Xiang;Zhouyu Li;Lu Zhu;Yan Ji;Peizeng Yang;Ke Hu
目的：评价低温灌注在葡萄膜炎所致白内障超声乳化术中的有效性和安全性。方法：这是一项前瞻性、单盲、随机、对照临床试验。106例葡萄膜炎相关性白内障患者接受了超声乳化术，灌注液温度为4 °C（治疗组）或24 °C（对照组）。观察术后第1、7天前房炎症分级、角膜内皮细胞计数、角膜厚度、黄斑中心凹厚度及眼压。结果如下：术后第1天，4 °C组的房水闪光评分为0.83 ± 0.76，低于24 °C组（1.51 ± 1.02，p = 0.006）。4 °C组的房水细胞评分（0.17 ± 0.38）低于24 °C组（0.62 ± 0.94，p = 0.025）。4 °C组切口的平均角膜厚度（907.66 ± 85.37 μm）薄于24 °C组（963.75 ± 103.81 μm，p = 0.005）。角膜内皮细胞密度、黄斑中心凹厚度和一过性眼压升高的百分比在两组之间无差异（p > 0.05）。术后第7天，两组的所有主要结局参数均无显著性差异（p > 0.05）。结论：低温灌注在葡萄膜炎相关性白内障超声乳化术中安全，能有效抑制术后早期前房炎症反应，减轻切口角膜水肿。
Background: To evaluate the effectiveness and safety of hypothermic perfusion in the phacoemulsification of cataract caused by uveitis..Methods: This was a prospective, single-masked, randomised, controlled clinical trial. One hundred and six patients with uveitis-associated cataract underwent phacoemulsification with perfusion fluid temperature at 4 °C (treatment group) or 24 °C (control group). Anterior chamber inflammation grade, corneal endothelial cell count, corneal thickness, macular fovea thickness, and intraocular pressure (IOP) were observed on the 1st day and 7th day after operation..Results: The aqueous flare score was 0.83 ± 0.76 in the 4 °C group, which was lower than that in the 24 °C group (1.51 ± 1.02, p = 0.006) on the first day after operation. The aqueous cells score was lower in the 4 °C group (0.17 ± 0.38) than that in the 24 °C group (0.62 ± 0.94, p = 0.025). The mean corneal thickness of incision in the 4 °C group (907.66 ± 85.37 μm) was thinner than that in the 24 °C group (963.75 ± 103.81 μm, p = 0.005). Corneal endothelial cells density, macular fovea thickness, or percentage of transiently increased IOP showed no difference between the two groups (p > 0.05). There was no significant difference in all the main outcome parameters between the two groups on the 7th day after operation (p > 0.05)..Conclusions: Hypothermic perfusion in the phacoemulsification of uveitis-associated cataract is safe, and it can effectively inhibit anterior chamber inflammation and reduce the incisional corneal edema in the early postoperative stage.
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影响因子：
5.3
作者：
通讯作者：
--
影响因子：
--
作者：
P. Jurowski;R. Goś;Katarzyna Kaszuba-Bartkowiak;Alicja Zeman-Miecznik
通讯作者：
P. Jurowski;R. Goś;Katarzyna Kaszuba-Bartkowiak;Alicja Zeman-Miecznik
影响因子：
13.7
作者：
A. Khodabakhsh;A. Khodabakhsh;G. Zaidman;G. Zaidman;G. Tabin
通讯作者：
A. Khodabakhsh;A. Khodabakhsh;G. Zaidman;G. Zaidman;G. Tabin
影响因子：
3.7
作者：
C. Foster;S. Rashid
通讯作者：
C. Foster;S. Rashid
DOI：
10.1007/978-3-319-71712-8_14
发表时间：
2018
期刊：
--
影响因子：
--
作者：
Cindy H. Hsu;Hasan B. Alam
通讯作者：
Cindy H. Hsu;Hasan B. Alam