Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis.
Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis.
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DOI：
10.1016/j.tranon.2021.101286
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发表时间：
2022-01
影响因子：
5
通讯作者：
Bond V
中科院分区：
文献类型：
--
作者：
Brena D;Huang MB;Bond V
细胞外小泡(EVS)在乳腺癌微环境和转移前生态位发展中的作用乳腺癌EV介导的转移和耐药表型的传播。以电动汽车为生物标记物的精准医学，以及药物和抗癌遗传物质的输送工具。乳腺癌转移到关键继发部位是女性癌症相关死亡的第二大原因。虽然现有的治疗方法在对抗原发肿瘤方面非常有效，但转移性疾病通常被认为是无法治愈的，中位生存期只有2到3年。广泛的努力集中于确定转移性贡献靶点，用于治疗拮抗和预防，以提高患者的存活率。乳腺癌过度释放细胞外小泡(EVS)，其内容刺激转移表型，是一个有希望的靶点。复杂的乳腺癌细胞间通讯网络建立在EV转运的基础上，分子信息的大量转运导致受体细胞内的完全重新编程事件。其他乳腺癌细胞可以获得侵袭性表型，内皮细胞可以被诱导形成小管，免疫细胞可以被中和。最近的进展继续暗示，EVS在培养适合癌症增殖、转移、免疫逃避和耐药会议的肿瘤微环境方面发挥着关键作用。该文献综述了EV转运在乳腺癌进展和转移中的作用。以下五个部分将被讨论：(1)发展肿瘤微环境中的细胞间通讯&转移前的生态位。(2)诱导上皮间充质转化(EMT)。(3)。免疫抑制和逃避。(4)耐药机制的传递。(5)精准医学：电动汽车的临床应用。
Extracellular vesicles’ (EVs) role in breast tumor microenvironment and pre-metastatic niche development. Breast cancer EV-mediated transmission of pro-metastatic and drug-resistant phenotypes. Precision medicine with EVs as biomarkers and delivery vehicles for drug and anticancer genetic material. Breast cancer metastatic progression to critical secondary sites is the second leading cause of cancer-related mortality in women. While existing therapies are highly effective in combating primary tumors, metastatic disease is generally deemed incurable with a median survival of only 2, 3 years. Extensive efforts have focused on identifying metastatic contributory targets for therapeutic antagonism and prevention to improve patient survivability. Excessive breast cancer release of extracellular vesicles (EVs), whose contents stimulate a metastatic phenotype, represents a promising target. Complex breast cancer intercellular communication networks are based on EV transport and transference of molecular information is in bulk resulting in complete reprogramming events within recipient cells. Other breast cancer cells can acquire aggressive phenotypes, endothelial cells can be induced to undergo tubule formation, and immune cells can be neutralized. Recent advancements continue to implicate the critical role EVs play in cultivating a tumor microenvironment tailored to cancer proliferation, metastasis, immune evasion, and conference of drug resistance. This literature review serves to frame the role of EV transport in breast cancer progression and metastasis. The following five sections will be addressed: (1) Intercellular communication in developing a tumor microenvironment & pre-metastatic niche. (2) Induction of the epithelial-to-mesenchymal transition (EMT). (3). Immune suppression & evasion. (4) Transmission of drug resistance mechanisms. (5) Precision medicine: clinical applications of EVs.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
来自耐药乳腺癌细胞的外泌体通过 MicroRNA 的水平转移传递化疗耐药性
影响因子：
3.7
作者：
Chen WX;Liu XM;Lv MM;Chen L;Zhao JH;Zhong SL;Ji MH;Hu Q;Luo Z;Wu JZ;Tang JH
通讯作者：
Tang JH
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
DOI：
10.1007/s10555-016-9639-8
发表时间：
2016-12
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
Chin AR;Wang SE
通讯作者：
Wang SE
影响因子：
7.3
作者：
Barros FM;Carneiro F;Machado JC;Melo SA
通讯作者：
Melo SA