Acetylcholine waves and dopamine release in the striatum.
Acetylcholine waves and dopamine release in the striatum.
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DOI：
10.1038/s41467-023-42311-5
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发表时间：
2023-10-27
影响因子：
16.6
通讯作者：
Goldberg, Joshua A.
中科院分区：
文献类型：
--
作者：
Matityahu, Lior;Gilin, Naomi;Sarpong, Gideon A.;Atamna, Yara;Tiroshi, Lior;Tritsch, Nicolas X.;Wickens, Jeffery R.;Goldberg, Joshua A.
纹状体多巴胺编码奖赏，最近的研究表明，多巴胺的释放发生在时空波中。然而，多巴胺波的机制尚不清楚。在此，我们报道了小鼠纹状体的乙酰胆碱释放也表现出波活动，并且烟碱型乙酰胆碱受体扩大了纹状体多巴胺释放的空间尺度。基于这些发现，以及我们证明单个胆碱能中间神经元可以诱导多巴胺释放，我们假设胆碱能中间神经元和多巴胺轴突之间的局部相互作用足以驱动内源性行波。我们发现，胆碱能神经元间-多巴胺轴突相互作用的形态和生理特性可以被模拟为产生行波的反应-扩散系统。分析容易处理的模型版本表明，乙酰胆碱和多巴胺行波的结构和传播性质取决于它们的耦合，行波可以在这些信号之间产生经验观察到的相关性。因此，我们的研究提供了体内纹状体乙酰胆碱波的证据，并提出了一个可测试的理论框架，预测所观察到的多巴胺和乙酰胆碱波是强耦合现象。多巴胺的释放发生在时空波中。在这里，作者提出多巴胺波在纹状体局部出现，并为纹状体乙酰胆碱波提供了证据。
Striatal dopamine encodes reward, with recent work showing that dopamine release occurs in spatiotemporal waves. However, the mechanism of dopamine waves is unknown. Here we report that acetylcholine release in mouse striatum also exhibits wave activity, and that the spatial scale of striatal dopamine release is extended by nicotinic acetylcholine receptors. Based on these findings, and on our demonstration that single cholinergic interneurons can induce dopamine release, we hypothesized that the local reciprocal interaction between cholinergic interneurons and dopamine axons suffices to drive endogenous traveling waves. We show that the morphological and physiological properties of cholinergic interneuron – dopamine axon interactions can be modeled as a reaction-diffusion system that gives rise to traveling waves. Analytically-tractable versions of the model show that the structure and the nature of propagation of acetylcholine and dopamine traveling waves depend on their coupling, and that traveling waves can give rise to empirically observed correlations between these signals. Thus, our study provides evidence for striatal acetylcholine waves in vivo, and proposes a testable theoretical framework that predicts that the observed dopamine and acetylcholine waves are strongly coupled phenomena. Dopamine release occurs in spatiotemporal waves. Here the authors propose that dopamine waves arise locally in the striatum, and provide evidence for striatal acetylcholine waves.
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影响因子：
16.2
作者：
Chuhma N;Mingote S;Moore H;Rayport S
通讯作者：
Rayport S
纹状体培养基神经元的功能连接组。
DOI：
10.1523/jneurosci.3833-10.2011
发表时间：
2011-01-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chuhma N;Tanaka KF;Hen R;Rayport S
通讯作者：
Rayport S
影响因子：
5.3
作者：
Chuhma, N;Zhang, H;Rayport, S
通讯作者：
Rayport, S
影响因子：
64.8
作者：
Chantranupong, Lynne;Beron, Celia C.;Zimmer, Joshua A.;Wen, Michelle J.;Wang, Wengang;Sabatini, Bernardo L.
通讯作者：
Sabatini, Bernardo L.
影响因子：
3.3
作者：
Contant, C;Umbriaco, D;Descarries, L
通讯作者：
Descarries, L