Duration of menopausal vasomotor symptoms over the menopause transition.
Duration of menopausal vasomotor symptoms over the menopause transition.
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绝经过渡期绝经血管舒缩症状的持续时间
DOI：
10.1001/jamainternmed.2014.8063
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发表时间：
2015-04
影响因子：
39
通讯作者：
Thurston, Rebecca C.
中科院分区：
文献类型：
--
作者：
Avis, Nancy E.;Crawford, Sybil L.;Greendale, Gail;Bromberger, Joyce T.;Everson-Rose, Susan A.;Gold, Ellen B.;Hess, Rachel;Joffe, Hadine;Kravitz, Howard M.;Tepper, Ping G.;Thurston, Rebecca C.
绝经期血管痉挛症状（VMS）的预期持续时间对妇女决定可能的治疗是重要的。确定绝经过渡期频繁VMS（前2周≥6天）的总持续时间（以下简称总VMS持续时间），量化末次月经期（FMP）后频繁VMS持续的时间（以下简称FMP后持续时间），并确定总VMS持续时间较长和FMP后持续时间较长的风险因素。全国妇女健康研究（SWAN）是一项多种族/多民族的观察性研究，在7个美国研究中心招募了3302名妇女。从1996年2月至2013年4月，妇女平均完成了13次就诊。分析包括1449名频繁VMS的女性。VMS总持续时间（年）（潮热或盗汗）和FMP后持续时间（年）至绝经后期。中位总VMS持续时间为7.4年。在881名经历过可观察到的FMP的女性中，FMP后的中位持续时间为4.5年。首次报告频繁VMS的绝经前或围绝经期早期女性的VMS总持续时间（中位数，>11.8年）和FMP后持续时间（中位数，9.4年）最长。绝经后妇女在VMS发病时的VMS总持续时间最短（中位数，3.4年）。与其他种族/族裔群体的女性相比，非裔美国女性报告的VMS总持续时间最长（中位数，10.1年）。与VMS持续时间较长相关的其他因素（总VMS持续时间或FMP后持续时间）是年龄较小，教育水平较低，更大的感知压力和症状敏感性，以及首次报告VMS时更高的抑郁症状和焦虑。在绝经过渡期，超过一半的妇女频繁的VMS持续了7年以上，并在FMP后持续了4.5年。个体特征（例如，绝经前和首次经历VMS时有更大的负面情感因素）与持续时间更长的VMS相关。卫生保健专业人员应建议妇女预期频繁的VMS可能持续7年以上，非洲裔美国妇女可能持续更长时间。
The expected duration of menopausal vasomotor symptoms (VMS) is important to women making decisions about possible treatments. To determine total duration of frequent VMS (≥6 days in the previous 2 weeks) (hereafter total VMS duration) during the menopausal transition, to quantify how long frequent VMS persist after the final menstrual period (FMP) (hereafter post-FMP persistence), and to identify risk factors for longer total VMS duration and longer post-FMP persistence. The Study of Women’s Health Across the Nation (SWAN) is a multiracial/multiethnic observational study of the menopausal transition among 3302 women enrolled at 7 US sites. From February 1996 through April 2013, women completed a median of 13 visits. Analyses included 1449 women with frequent VMS. Total VMS duration (in years) (hot flashes or night sweats) and post-FMP persistence (in years) into postmenopause. The median total VMS duration was 7.4 years. Among 881 women who experienced an observable FMP, the median post-FMP persistence was 4.5 years. Women who were premenopausal or early perimenopausal when they first reported frequent VMS had the longest total VMS duration (median, >11.8 years) and post-FMP persistence (median, 9.4 years). Women who were postmenopausal at the onset of VMS had the shortest total VMS duration (median, 3.4 years). Compared with women of other racial/ethnic groups, African American women reported the longest total VMS duration (median, 10.1 years). Additional factors related to longer duration of VMS (total VMS duration or post-FMP persistence) were younger age, lower educational level, greater perceived stress and symptom sensitivity, and higher depressive symptoms and anxiety at first report of VMS. Frequent VMS lasted more than 7 years during the menopausal transition for more than half of the women and persisted for 4.5 years after the FMP. Individual characteristics (eg, being premenopausal and having greater negative affective factors when first experiencing VMS) were related to longer-lasting VMS. Health care professionals should counsel women to expect that frequent VMS could last more than 7 years, and they may last longer for African American women.
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全国妇女健康的研究中，负面影响和血管舒缩症状每日荷尔蒙研究。
DOI：
10.1097/gme.0b013e3182230e42
发表时间：
2011-12
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Gibson CJ;Thurston RC;Bromberger JT;Kamarck T;Matthews KA
通讯作者：
Matthews KA
影响因子：
12.7
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
通讯作者：
Matthews, Karen
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
7.2
作者：
Freeman EW;Sammel MD;Lin H;Liu Z;Gracia CR
通讯作者：
Gracia CR
DOI：
10.1097/gme.0b013e3182730599
发表时间：
2013-05
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Bromberger JT;Kravitz HM;Chang Y;Randolph JF Jr;Avis NE;Gold EB;Matthews KA
通讯作者：
Matthews KA