Microarray-based gene expression profiling to elucidate effectiveness of fermented Codonopsis lanceolata in mice.
Microarray-based gene expression profiling to elucidate effectiveness of fermented Codonopsis lanceolata in mice.
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DOI：
10.3390/ijms15045907
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发表时间：
2014-04-08
影响因子：
5.6
通讯作者：
Lee HY
中科院分区：
文献类型：
--
作者：
Choi WY;Kim JS;Park SJ;Ma CJ;Lee HY
本研究采用寡核苷酸芯片芯片技术，观察了乳酸发酵的杉树党参对肥胖相关基因表达水平的调控作用。8170个基因中，393个基因上调，760个基因下调。另外374个基因被上调，527个基因被下调。这些基因不受FCL样品的影响。有趣的是，在这些基因中，Chytochrome P450、Dmbt1、LOC76487、甲状腺激素等基因大多上调或下调。这些基因与脂质合成更相关。我们可以得出结论，FCL可能控制与脂质合成相关的基因表达水平，从而导致肥胖的减少。但是，还需要进行更详细的蛋白表达实验。
In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out.
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影响因子：
4.4
作者：
He, Zhili;Zhou, Jizhong
通讯作者：
Zhou, Jizhong
影响因子：
82.9
作者：
Maeda, N;Shimomura, I;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
6.1
作者：
Lee, KT;Choi, J;Park, HJ
通讯作者：
Park, HJ
影响因子：
4.4
作者：
He, ZL;Wu, LY;Zhou, JZ
通讯作者：
Zhou, JZ
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1.8
作者：
Pfaffl, M;Meyer, HHD;Sauerwein, H
通讯作者：
Sauerwein, H