Magnitude of daily energy deficit predicts frequency but not severity of menstrual disturbances associated with exercise and caloric restriction.
Magnitude of daily energy deficit predicts frequency but not severity of menstrual disturbances associated with exercise and caloric restriction.
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每日能量不足的程度可以预测与运动和热量限制相关的月经紊乱的频率，但不能预测其严重程度。
DOI：
10.1152/ajpendo.00386.2013
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
DeSouza,MaryJane
中科院分区：
文献类型：
--
作者：
Williams,NancyI;Leidy,HeatherJ;Hill,BrennaR;Lieberman,JayL;Legro,RichardS;DeSouza,MaryJane
我们在18-30岁的未经训练的月经来潮妇女中，通过控制喂养和监督运动，评估了能量缺乏对月经功能的影响，包括4个月经周期（1个基线和3个干预周期）。受试者被随机分配到运动对照组（EXCON）或三个运动能量不足（艾德）组之一，即，轻度（ED 1; −8 ± 2%）、中度（ED 2; −22 ± 3%）或重度（ED 3; −42 ± 3%）。评估月经周期长度和雌酮-1-葡萄糖醛酸苷、孕激素葡萄糖醛酸苷和周期中期促黄体激素尿浓度的变化。34例受试者完成了研究。ED 1（−3.8 ± 0.2 kg）、ED 2（−2.8 ± 0.6 kg）和ED 3（−2.6 ± 1.1 kg）中出现体重减轻，但EXCON（−0.9 ± 0.7 kg）中的体重减轻程度极轻微。ED 2中的紊乱（黄体功能不全、无排卵和月经过少）总和大于EXCON，ED 3中的紊乱总和大于EXCON和ED 1。平均能量不足百分比是月经紊乱频率的主要预测因素（f = 10.1，β =-0.48，r2 = 0.23，P = 0.003），即使模型中包括体重减轻。与月经紊乱相关的能量缺乏程度的估计值范围为-22（ED 2）至-42%（ED 3），分别反映了-470至-810千卡/天的能量不足。这是第一项证明能量缺乏程度与运动相关月经紊乱频率之间存在剂量反应关系的研究;然而，月经紊乱的严重程度并不取决于能量缺乏的程度。
We assessed the impact of energy deficiency on menstrual function using controlled feeding and supervised exercise over four menstrual cycles (1 baseline and 3 intervention cycles) in untrained, eumenorrheic women aged 18–30 yr. Subjects were randomized to either an exercising control (EXCON) or one of three exercising energy deficit (ED) groups, i.e., mild (ED1; −8 ± 2%), moderate (ED2; −22 ± 3%), or severe (ED3; −42 ± 3%). Menstrual cycle length and changes in urinary concentrations of estrone-1-glucuronide, pregnanediol glucuronide, and midcycle luteinizing hormone were assessed. Thirty-four subjects completed the study. Weight loss occurred in ED1 (−3.8 ± 0.2 kg), ED2 (−2.8 ± 0.6 kg), and ED3 (−2.6 ± 1.1 kg) but was minimal in EXCON (−0.9 ± 0.7 kg). The overall sum of disturbances (luteal phase defects, anovulation, and oligomenorrhea) was greater in ED2 compared with EXCON and greater in ED3 compared with EXCON AND ED1. The average percent energy deficit was the main predictor of the frequency of menstrual disturbances (f = 10.1, β = −0.48,r2= 0.23,P= 0.003) even when weight loss was included in the model. The estimates of the magnitude of energy deficiency associated with menstrual disturbances ranged from −22 (ED2) to −42% (ED3), reflecting an energy deficit of −470 to −810 kcal/day, respectively. This is the first study to demonstrate a dose-response relationship between the magnitude of energy deficiency and the frequency of exercise-related menstrual disturbances; however, the severity of menstrual disturbances was not dependent on the magnitude of energy deficiency.
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DOI：
10.1056/nejmoa0911064
发表时间：
2011-01-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Caronia LM;Martin C;Welt CK;Sykiotis GP;Quinton R;Thambundit A;Avbelj M;Dhruvakumar S;Plummer L;Hughes VA;Seminara SB;Boepple PA;Sidis Y;Crowley WF Jr;Martin KA;Hall JE;Pitteloud N
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Pitteloud N
能量缺乏对绝经前女性雌激素代谢的影响。
影响因子：
4.1
作者：
K. Westerlind;N. Williams
通讯作者：
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剧烈运动训练期间低能量可用性导致月经周期紊乱的因果作用的证据。
DOI：
10.1210/jcem.86.11.8024
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Williams,NI;Helmreich,DL;Parfitt,DB;Caston-Balderrama,A;Cameron,JL
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Cameron,JL
25-40 岁女性因能量缺乏而减少雌激素和孕激素的暴露。
DOI：
10.1093/humrep/deq172
发表时间：
2010
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Williams,NI;Reed,JL;Leidy,HJ;Legro,RS;DeSouza,MJ
通讯作者：
DeSouza,MJ
月经正常的女性生殖轴在 1 年耐力训练期间的耐久性。
DOI：
10.1152/jappl.1992.72.4.1571
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Rogol,AD;Weltman,A;Weltman,JY;Seip,RL;Snead,DB;Levine,S;Haskvitz,EM;Thompson,DL;Schurrer,R;Dowling,E
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Dowling,E