Effect of energy deficiency on estrogen metabolism in premenopausal women.
Effect of energy deficiency on estrogen metabolism in premenopausal women.
复制标题
能量缺乏对绝经前女性雌激素代谢的影响。
DOI：
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发表时间：
2007
影响因子：
4.1
通讯作者：
N. Williams
中科院分区：
文献类型：
--
作者：
K. Westerlind;N. Williams
目的
体力活动与乳腺癌风险降低有关，可能是通过雌激素代谢的变化。2-羟基雌酮（2-OHE 1）和16 α-羟基雌酮（16 α-OHE 1）具有不同的生物学特性，这些代谢产物的比例（2/16）已被提议用于预测乳腺癌风险。饮食和运动已被发现影响雌激素代谢，特别是当达到负能量平衡的状态时。我们试图确定4个月的中等强度运动加上热量限制是否会导致久坐、绝经前、月经过多的女性尿2-OHE 1、16 α-OHE 1或2/16的变化。
方法
平均年龄为31.5岁，平均体脂率为31.6%，平均BMI为23.7。在24名妇女的基线和4个月的干预措施中，在卵泡中期和黄体中期测量尿雌激素代谢产物。
结果
干预措施使体脂（4.5%）和体重（3.7 kg）显著下降。有氧适应能力显著提高（26%; P < 0.001）。总体而言，饮食和运动干预对2-OHE 1、16 α-OHE 1或2/16没有显着影响。然而，当根据基线2/16分为三分位数时，干预导致最低三分位数的女性中2/16显着增加。最低三分位数的妇女（平均2/16 = 0.91）在基线雌二醇浓度、体脂、体重、健身或这些变量的干预变化方面与其他三分位数没有差异。
结论
这些数据表明，由于低2/16而患乳腺癌风险较高的女性可以通过参与生活方式干预（如运动/卡路里限制）来降低风险。
PURPOSE
Physical activity has been associated with decreased breast cancer risk, potentially through changes in estrogen metabolism. Two-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1) have different biological properties, and the ratio of these metabolites (2/16) has been proposed to predict breast cancer risk. Diet and exercise have been found to influence estrogen metabolism, particularly when a state of negative energy balance is achieved. We sought to determine whether 4 months of moderate-intensity exercise coupled with calorie restriction would result in changes in urinary 2-OHE1, 16alpha-OHE1, or 2/16 in sedentary, premenopausal, eumenorrheic women.
METHODS
Average age was 31.5 yr, average body fat was 31.6%, and average BMI was 23.7. Urinary estrogen metabolites were measured in 24 women during the baseline and for four intervention months in the midfollicular and midluteal phases.
RESULTS
The intervention produced a significant drop in body fat (4.5%) and body weight (3.7 kg). Aerobic fitness increased significantly (26%; P < 0.001). Overall, there were no significant effects of the diet and exercise intervention on 2-OHE1, 16alpha-OHE1, or 2/16. However, when divided into tertiles according to baseline 2/16, the intervention resulted in significant increases in 2/16 in women in the lowest tertile. Women in the lowest tertile (average 2/16 = 0.91) did not differ from the other tertiles in baseline estradiol concentrations, body fat, weight, fitness, or changes in these variables with the intervention.
CONCLUSION
The data suggest that women at higher risk for developing breast cancer because of low 2/16 may reduce their risk by participating in lifestyle interventions such as exercise/calorie restriction.
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尿雌激素代谢物与乳腺癌：病例对照研究。
DOI：
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发表时间：
1997
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Kabat,GC;Chang,CJ;Sparano,JA;Sepkovie,DW;Hu,XP;Khalil,A;Rosenblatt,R;Bradlow,HL
通讯作者：
Bradlow,HL
绝经前女性在食用含有异黄酮的大豆饮食期间，尿液中 2-羟基雌酮的排泄量增加，但 16α-羟基雌酮的排泄量却没有增加。
影响因子：
11.2
作者：
Lu,LJ;Cree,M;Josyula,S;Nagamani,M;Grady,JJ;Anderson,KE
通讯作者：
Anderson,KE
影响因子：
5.5
作者：
PIKE, MC;SPICER, DV;PRESS, MF
通讯作者：
PRESS, MF
中等强度运动干预对绝经后女性雌激素代谢的影响。
DOI：
--
发表时间：
2004
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Atkinson,Charlotte;Lampe,JohannaW;Tworoger,ShelleyS;Ulrich,CorneliaM;Bowen,Deborah;Irwin,MelindaL;Schwartz,RobertS;Rajan,BharatK;Yasui,Yutaka;Potter,JohnD;McTiernan,Anne
通讯作者：
McTiernan,Anne
大豆消费改变绝经后妇女的内源性雌激素代谢。
DOI：
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发表时间：
2000
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Xu,X;Duncan,AM;Wangen,KE;Kurzer,MS
通讯作者：
Kurzer,MS