Focus on vitamin D, inflammation and type 2 diabetes.
Focus on vitamin D, inflammation and type 2 diabetes.
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DOI：
10.3390/nu4010052
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发表时间：
2012-01
期刊：
影响因子：
5.9
通讯作者：
Rogero MM
中科院分区：
文献类型：
--
作者：
Chagas CE;Borges MC;Martini LA;Rogero MM
将维生素D与人类2型糖尿病联系起来的最初观察来自于研究，研究表明健康和糖尿病受试者的血糖控制都有季节性变化。目前，有证据支持维生素D状态对调节与2型糖尿病发展相关的一些途径很重要。由于炎症通路的激活会干扰正常的代谢并破坏适当的胰岛素信号，因此假设维生素D可能通过调节炎症反应来影响葡萄糖稳态。研究补充维生素D对2型糖尿病患者或高风险受试者炎症生物标志物影响的人类研究很少，并且产生了相互矛盾的结果。根据现有的临床和流行病学数据，维生素D的积极作用似乎主要与它对胰岛素分泌和敏感性的作用有关，其次是它对炎症的作用。为了在维生素D、炎症和2型糖尿病之间提供更有力的联系，迫切需要未来专门设计的研究，以炎症为主要结果来研究维生素D对2型糖尿病的作用。
The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.
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