Non-uniform upregulation of the autogenic stretch reflex among hindlimb extensors following lateral spinal lesion in the cat.
Non-uniform upregulation of the autogenic stretch reflex among hindlimb extensors following lateral spinal lesion in the cat.
复制标题
猫脊髓外侧损伤后后肢伸肌自发牵张反射的不均匀上调。
DOI：
10.1007/s00221-020-06016-1
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发表时间：
2021-09
影响因子：
2
通讯作者：
Nichols, T. Richard
中科院分区：
文献类型：
--
作者：
Kajtaz, E.;Montgomery, L. R.;McMurtry, S.;Howland, D. R.;Nichols, T. Richard
整个步周期的成功传播取决于本体感受反馈对整个肢体刚度的充分调节。脊髓损伤（SCI）后，本体感受反馈的强度和组织发生变化，可导致关节僵硬度改变。在这项研究中，我们测量了去大脑猫慢性下胸外侧半切（LSH）后五块后肢伸肌自体反馈的变化。我们提出了三个特点的自体牵张反射获得使用机械的方法。刚度是在长度变化期间抗拉伸性的量度。动态指数记录了保持阶段期间力响应的适应或增加的程度，并且脉冲测量了从拉伸开始到返回到初始长度的响应的积分。这些变化表现为股肌（VASTI）组、比目鱼肌（SOL）和拇长屈肌（FHL）僵硬度的可变和短暂增加，以及适应性增加（VASTI）或降低（GAS和PLANT）。腓肠肌组（GAS）的僵硬度也随时间变化，但在最终时间点保持升高。一个意想不到的发现是，这些影响是双边观察。这一发现的潜在原因和可能的来源增加兴奋性，这一肌肉群进行了讨论。
Successful propagation throughout the step cycle is contingent on adequate regulation of whole-limb stiffness by proprioceptive feedback. Following spinal cord injury (SCI), there are changes in the strength and organization of proprioceptive feedback that can result in altered joint stiffness. In this study, we measured changes in autogenic feedback of five hindlimb extensor muscles following chronic low thoracic lateral hemisection (LSH) in decerebrate cats. We present three features of the autogenic stretch reflex obtained using a mechanographic method. Stiffness was a measure of the resistance to stretch during the length change. The dynamic index documented the extent of adaptation or increase of the force response during the hold phase, and the impulse measured the integral of the response from initiation of a stretch to the return to the initial length. The changes took the form of variable and transient increases in the stiffness of vastus (VASTI) group, soleus (SOL), and flexor hallucis longus (FHL), and either increased (VASTI) or decreased adaptation (GAS and PLANT). The stiffness of the gastrocnemius group (GAS) was also variable over time but remained elevated at the final time point. An unexpected finding was that these effects were observed bilaterally. Potential reasons for this finding and possible sources of increased excitability to this muscle group are discussed.
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影响因子：
3.3
作者：
Krenz, NR;Weaver, LC
通讯作者：
Weaver, LC
影响因子：
2.5
作者：
Bennett, DJ;Li, YR;Gorassini, M
通讯作者：
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作者：
ECCLES, RM;LUNDBERG, A
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作者：
Doperalski, Adele E.;Tester, Nicole J.;Howland, Dena R.
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影响因子：
11
作者：
BURKE, D;GILLIES, JD;LANCE, JW
通讯作者：
LANCE, JW