The Impact of Alcohol Use on Frontal White Matter in HIV.
The Impact of Alcohol Use on Frontal White Matter in HIV.
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DOI：
10.1111/acer.13823
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Cohen RA
中科院分区：
文献类型：
--
作者：
Gullett JM;Lamb DG;Porges E;Woods AJ;Rieke J;Thompson P;Jahanshad N;Nir TM;Tashima K;Cohen RA
酒精使用障碍（AUD）在被诊断患有人类免疫缺陷病毒（HIV）的个体中普遍存在，并且已证明HIV和酒精使用都会对大脑中白色物质通路的完整性产生负面影响。行为、功能和解剖学上的损伤已经独立地与艾滋病毒和酒精使用相关联，并且这些损伤在大脑内特定的前部介导的通路中具有基础。磁共振成像（MRI）数据采集了37名HIV+参与者，没有痴呆或丙型肝炎。通过FreeSurfer和TraCULA管道处理成像数据，以获得每位参与者的四个双侧额叶白色物质束。根据人口统计学、疾病特异性变量和报告的物质使用情况，分析了白色物质完整性沿着每条管道的最高概率途径的扩散指标。在有AUD病史的受试者中，观察到轴向扩散率（AD;轴突完整性降低）显著增加和平均扩散率（MD）沿前丘脑辐射（ATR）沿着趋势增加。当考虑到包括最低点CD 4和年龄调整的HIV感染长度在内的临床变量时，AUD的诊断解释了整个前丘脑辐射沿着扩散率的36%以上的方差。本研究提供了HIV相关的关联酒精使用和轴突完整性损失的指标沿着ATR，一个额叶通路参与成瘾或不想要的行为的抑制之间的证据。该通路的轴突完整性降低在患有AUD的HIV+参与者中最大，即使考虑到年龄调整的疾病长度和严重程度的影响（最低CD 4）。这一发现暗示了一种潜在的生物学机制，将额叶白色物质的完整性降低与无痴呆或丙型肝炎的HIV+人群中AUD的高患病率联系起来。
Alcohol use disorder (AUD) is prevalent among individuals diagnosed with human immunodeficiency virus (HIV), and both HIV and alcohol use have been shown to negatively affect the integrity of white matter pathways in the brain. Behavioral, functional, and anatomical impairments have been linked independently to HIV and alcohol use, and these impairments have bases in specific frontally-mediated pathways within the brain. Magnetic Resonance Imaging (MRI) data were acquired for 37 HIV+ participants without dementia or hepatitis C. Imaging data were processed through the FreeSurfer and TraCULA pipelines to obtain four bilateral frontal white matter tracts for each participant. Diffusion metrics of white matter integrity along the highest probability pathway for each tract were analyzed with respect to demographics, disease-specific variables, and reported substance use. Significantly increased Axial Diffusivity (AD; decreased axonal integrity) and a trending increase in Mean Diffusivity (MD) were observed along the Anterior Thalamic Radiation (ATR) in participants with a history of AUD. A diagnosis of AUD explained over 36% of the variance in diffusivity along the Anterior Thalamic Radiation overall when accounting for clinical variables including Nadir CD4 and age-adjusted HIV infection length. The present study provides evidence of HIV-related associations between alcohol use and indicators of axonal integrity loss along the ATR, a frontal pathway involved in the inhibition of addictive or unwanted behaviors. Reduced axonal integrity of this pathway was greatest in HIV+ participants with an AUD, even when considering the effect of age-adjusted disease length and severity (Nadir CD4). This finding implicates a potential biological mechanism linking reduced integrity of frontal white matter to the high prevalence of AUD in an HIV+ population without dementia or hepatitis C.
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影响因子：
3.2
作者：
Cohen RA;Harezlak J;Schifitto G;Hana G;Clark U;Gongvatana A;Paul R;Taylor M;Thompson P;Alger J;Brown M;Zhong J;Campbell T;Singer E;Daar E;McMahon D;Tso Y;Yiannoutsos CT;Navia B
通讯作者：
Navia B
DOI：
10.15288/jsa.2002.63.179
发表时间：
2002-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Galvan, FH;Bing, EG;Shapiro, M
通讯作者：
Shapiro, M
影响因子：
14.5
作者：
Harding, A;Halliday, G;Kril, J
通讯作者：
Kril, J
影响因子：
2.8
作者：
Della Nave, Riccardo;Ginestroni, Andrea;Mascalchi, Mario
通讯作者：
Mascalchi, Mario
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR