Inner ear cell therapy targeting hereditary deafness by activation of stem cell homing factors.
Inner ear cell therapy targeting hereditary deafness by activation of stem cell homing factors.
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DOI：
10.3389/fphar.2015.00002
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发表时间：
2015
影响因子：
5.6
通讯作者：
Kamiya K
中科院分区：
文献类型：
--
作者：
Kamiya K
每1000名儿童中就有1名患有先天性耳聋，其中一半以上的儿童具有Connexin26 （CX26）基因突变等遗传背景。内耳细胞治疗感音神经性听力损失有望成为遗传性耳聋的有效治疗方法。在此之前，我们开发了一种新的内耳细胞治疗策略，使用骨髓间充质干细胞作为耳蜗纤维细胞的补充，用于耳蜗离子运输。对于针对遗传性耳聋的细胞治疗，需要一种更有效的细胞传递系统来诱导干细胞进入耳蜗组织，因为基因突变会影响所有的耳蜗细胞，耳蜗细胞表达GJB2编码CX26等基因。干细胞归巢是激活细胞有效递送到耳蜗组织的关键机制之一。在我们的研究中，单核细胞趋化蛋白-1、基质细胞衍生因子-1及其受体被发现是干细胞向耳蜗组织募集的关键调节因子。因此，激活干细胞归巢可能是遗传性耳聋患者听力恢复的有效策略。
Congenital deafness affects about 1 in 1000 children and more than half of them have a genetic background such as Connexin26 (CX26) gene mutation. Inner ear cell therapy for sensorineural hearing loss has been expected to be an effective therapy for hereditary deafness. Previously, we developed a novel strategy for inner ear cell therapy using bone marrow mesenchymal stem cells as a supplement for cochlear fibrocytes functioning for cochlear ion transport. For cell therapy targeting hereditary deafness, a more effective cell delivery system to induce the stem cells into cochlear tissue is required, because gene mutations affect all cochlear cells cochlear cells expressing genes such as GJB2 encoding CX26. Stem cell homing is one of the crucial mechanisms to be activated for efficient cell delivery to the cochlear tissue. In our study, monocyte chemotactic protein-1, stromal cell-derived factor-1 and their receptors were found to be a key regulator for stem cell recruitment to the cochlear tissue. Thus, the activation of stem cell homing may be an efficient strategy for hearing recovery in hereditary deafness.
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