Association between maternal polycystic ovary syndrome and early childhood growth: a continuous observation from 3 months to 6 years of age
Association between maternal polycystic ovary syndrome and early childhood growth: a continuous observation from 3 months to 6 years of age
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母亲多囊卵巢综合征与儿童早期生长的关联：3个月至6岁的连续观察
DOI：
10.1007/s10815-021-02378-9
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发表时间：
2022-01
影响因子：
3.1
通讯作者：
Qu Fan
中科院分区：
文献类型：
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作者：
Zhang Fangfang;Ying Liying;Zhang Qing;Wang Fangfang;Qu Fan
为探讨母亲多囊卵巢综合征(PCOS)对子代早期生长发育的影响，对浙江省宁波市多囊卵巢综合征(PCOS)母亲所生的198名儿童和健康母亲所生的227名儿童进行了前瞻性研究。受过训练的专业人员在6岁期间对后代的身高、体重、头围和牙齿进行了测量。对多囊卵巢综合征组和对照组的身高、体重和体重指数进行重复测量方差分析。多囊卵巢综合征患者所生子女在12、18、30个月和5岁时的体重指数显著高于对照组(分别为P=0.040、P=0.000、P=0.000和P=0.023)。多囊卵巢综合征患者生下的女婴在3、8、12、18、30个月和3、6岁时体重显著增加(P=0.027，P=0.008，P=0.010，P=0.034，P=0.047，P=0.040，P=0.035)，体重指数在3，8，12，18，30个月时显著增加(分别为P=0.009，P=0.016，P=0.029，P=0.000，P=0.000)。在调整了母亲、父亲和怀孕的混杂因素后，女性子代的多囊卵巢综合征状态与3、8、12个月和3岁时的体重(分别为P=0.005、P=0.004、P=0.021、P=0.035)以及3个月和8个月的体重指数(P=0.011和P=0.014)显著相关。母亲多囊卵巢综合征与女性后代肥胖的风险增加有关。
To investigate whether maternal PCOS could impact growth and development in offspring at an early age through continuous observation from age 3 months to 6 years.This prospective study was conducted in 198 children born to mothers with PCOS and 227 children born to healthy mothers in Ningbo (Zhejiang Province, China) between October 2012 and July 2015. Measurements of offspring height, weight, head circumference, and teething were examined by trained professionals through age 6 years. Height, weight, and body mass index (BMI) were analysed using repeated measures analysis of variance between the PCOS and control groups.Offspring born to women with PCOS showed significantly higher BMI at age 12, 18, and 30 months and 5 years (P = 0.040, P = 0.000, P = 0.000, and P = 0.023, respectively). Female offspring born to women with PCOS showed significantly increased body weight at 3, 8, 12, 18, and 30 months, and 3 and 6 years (P = 0.027, P = 0.008, P = 0.010, P = 0.034, P = 0.047, P = 0.040, and P = 0.035, respectively) and significantly higher BMI at 3, 8, 12, 18, and 30 months (P = 0.009, P = 0.016, P = 0.029, P = 0.000, and P = 0.000, respectively). After adjusting for maternal, paternal, and pregnancy confounders, PCOS status presented significant associations with weight at age 3, 8, and 12 months and 3 years (P = 0.005, P = 0.004, P = 0.021, P = 0.035 respectively), and with BMI at age 3 and 8 months (P = 0.011 and P = 0.014) in female offspring.Maternal PCOS is associated with an increased risk of developing obesity in female offspring.
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