Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System.
Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System.
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聚乙烯醇/5-氟尿嘧啶/锌铝层状双氢氧化物包覆的双功能氧化铁纳米颗粒用于同时给药和靶向递送系统。
DOI：
10.3390/polym13060855
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发表时间：
2021-03-10
期刊：
影响因子：
5
通讯作者：
Pastorin G
中科院分区：
文献类型：
--
作者：
Ebadi M;Bullo S;Buskaran K;Hussein MZ;Fakurazi S;Pastorin G
氧化铁纳米颗粒由于其锚定各种活性剂和药物的能力、独特的磁性、无毒和生物相容性而适用于生物医学应用。本文研究了负载5-氟尿嘧啶（5-FU）抗癌药物的Fe3O4纳米颗粒包被聚合物载体的物理化学性质、磁性能以及细胞毒性。合成的Fe3O4纳米粒子包被聚乙烯醇和锌/铝层状双氧根作为药物宿主。XRD、DTA/TG和FTIR分析证实了纳米颗粒表面存在包覆层。结果表明：PVA/5FU/Zn/Al-LDH包覆后，Fe3O4纳米粒子的饱和磁化强度降低；此外，涂层的存在阻止了纳米颗粒的聚集。此外，准二阶方程控制了药物释放动力学。最后，与裸5-FU相比，包被的纳米颗粒对肝癌细胞（HepG2）表现出更强的活性，对3T3成纤维细胞系没有细胞毒性。本研究的结果证明了纳米递送系统用于癌症治疗的潜力。
Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.
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影响因子：
8
作者：
Megat Nabil Mohsin S;Hussein MZ;Sarijo SH;Fakurazi S;Arulselvan P;Taufiq-Yap YH
通讯作者：
Taufiq-Yap YH
全反式视黄酸和阿霉素联合递送用于癌症治疗并协同抑制癌症干细胞
影响因子：
14
作者：
Sun, Rong;Liu, Yang;Wang, Jun
通讯作者：
Wang, Jun
DOI：
10.1016/b978-0-12-813741-3.00010-8
发表时间：
2018-01-01
期刊：
APPLICATIONS OF NANOCOMPOSITE MATERIALS IN DRUG DELIVERY
影响因子：
--
作者：
Lim, Keemi;Hamid, Zuratul A. A.
通讯作者：
Hamid, Zuratul A. A.
影响因子：
3.1
作者：
Jeevanandam J;Barhoum A;Chan YS;Dufresne A;Danquah MK
通讯作者：
Danquah MK
影响因子：
4.1
作者：
Tummala, Shashank;Kumar, M. N. Satish;Prakash, Ashwati
通讯作者：
Prakash, Ashwati