Evidence that mammalian lignans show endogenous digitalis-like activities.
Evidence that mammalian lignans show endogenous digitalis-like activities.
复制标题
有证据表明哺乳动物木脂素表现出内源性洋地黄样活性。
DOI：
10.1016/0006-291x(86)90359-1
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发表时间：
1986
影响因子：
3.1
通讯作者：
T. Godfraind
中科院分区：
文献类型：
--
作者：
M. Fagoo;P. Braquet;J. Robin;A. Esanu;T. Godfraind
Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+,K+-ATPase activity of human and guinea-pig heart. The time dependence of this inhibition ressembles that of dihydroouabain, a cardiac glycoside in which the lactone ring does not contain conjugated double bonds. The active concentrations of enterolactone as inhibitor of Na+,K+-ATPase are in the 10−4M range and, at those concentrations, the cross-reactivity with antidigoxin antibodies is low. Lignans may contribute to the putative digitalis-like activity found in tissues, blood and urine of several mammals including man.
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kelly,RA;O'Hara,DS;Canessa,ML;Mitch,WE;Smith,TW
通讯作者：
Smith,TW
抗坏血酸：分离的 Na ,K -ATP 酶的内源性抑制剂。
影响因子：
5.8
作者：
Ng,YC;Akera,T;Han,CS;Braselton,WE;Kennedy,RH;Temma,K;Brody,TM;Sato,PH
通讯作者：
Sato,PH
醋酸氯地孕酮与 Na ,K -ATP 酶哇巴因结合位点的相互作用。
影响因子：
3.6
作者：
Wehling,M;Schwartz,A;Whitmer,K;Grupp,G;Grupp,IL;Wallick,ET
通讯作者：
Wallick,ET